Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?

Autor(es)

Yamada Yoshikawa, Fabio Seiti ^[1] ; Emidio Teixeira, Franciane Mouradian ^[1] ; Sato, Maria Notomi ^[1] ; da Silva Oliveira, Luanda Mara ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Trop Med Inst, Lab Dermatol & Immunodeficiencies, Dept Dermatol, BR-05403000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLS; v. 8, n. 6 JUN 2019.
• Citações Web of Science: 0

Resumo

Extracellular vesicles (EVs) are released by various cells and recently have attracted attention because they constitute a refined system of cell-cell communication. EVs deliver a diverse array of biomolecules including messenger RNAs (mRNAs), microRNAs (miRNAs), proteins and lipids, and they can be used as potential biomarkers in normal and pathological conditions. The cargo of EVs is a snapshot of the donor cell profile; thus, in viral infections, EVs produced by infected cells could be a central player in disease pathogenesis. In this context, miRNAs incorporated into EVs can affect the immune recognition of viruses and promote or restrict their replication in target cells. In this review, we provide an updated overview of the roles played by EV-delivered miRNAs in viral infections and discuss the potential consequences for the host response. The full understanding of the functions of EVs and miRNAs can turn into useful biomarkers for infection detection and monitoring and/or uncover potential therapeutic targets. (AU)

• Processo FAPESP: 16/16840-6 - Análise de fatores antivirais e exossomas em trofoblastos e monócitos de recém-natos na infecção in vitro por Zika vírus
• Beneficiário: Maria Notomi Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/10522-2 - Caracterização proteômica de exossomas e seus miRNAs inflamatórios de trofoblastos extravilosos infectados in vitro por Zika vírus
• Beneficiário: Luanda Mara da Silva Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado