Association of apolipoproteins C-I, C-II, C-III and E with coagulation markers and venous thromboembolism risk

Autor(es)

Orsi, Fernanda A. ^{[1, 2]} ; Lijfering, Willem M. ^{[2, 3]} ; Van der Laarse, Arnoud ^{[4, 5]} ; Ruhaak, L. Renee ^[5] ; Rosendaal, Frits R. ^[2] ; Cannegieter, Suzanne C. ^{[2, 6, 3]} ; Cobbaert, Christa ^[5]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, Campinas, SP - Brazil

^[2] Leiden Univ, Med Ctr, Dept Clin Epidemiol, POB 9600, NL-2300 RC Leiden - Netherlands

^[3] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, Leiden - Netherlands

^[4] Leiden Univ, Med Ctr, Dept Cardiol, Leiden - Netherlands

^[5] Leiden Univ, Med Ctr, Dept Clin Chem & Lab Med, Leiden - Netherlands

^[6] Leiden Univ, Med Ctr, Sect Thrombosis & Hemostasis, Dept Internal Med, Leiden - Netherlands

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL EPIDEMIOLOGY; v. 11, p. 625-633, 2019.
• Citações Web of Science: 0

Resumo

Purpose: Apolipoproteins C-I, C-II, C-III and E have been associated with risk of arterial thrombotic diseases. We investigated whether these apolipoproteins have prothrombotic properties and are associated with risk of venous thromboembolism (VTE). Patients and methods: A total of 127 VTE patients and 299 controls were randomly selected from the Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis study (1999-2004), in the Netherlands. The apolipoproteins were quantified using mass spectrometry (LC/MS/MS), and their levels were analyzed as continuous variable (per SD increase). Results: In controls, increases in levels of apolipoproteins were associated with increases in levels of vitamin K-dependent factors, factor XI, antithrombin and clot lysis time. Additionally, increasing apolipoproteins C-III and E levels were associated with higher factor VIII and von Willebrand factor levels. Levels of C-reactive protein were not associated with any apolipoprotein. The age-and sex-adjusted odds ratios of apolipoproteins E, C-III, CII and CI to the risk of venous thrombosis were 1.21 (95% CI, 0.98-1.49), 1.19 (95% CI, 0.99-1.44), 1.24 (95% CI, 0.95-1.61) and 1.06 (95% CI, 0.87-1.30) per SD increase, respectively. These odds ratios did not attenuate after adjustments for statin use, estrogen use, BMI, alcohol use, and self-reported diabetes. Conclusions: Levels of apolipoproteins C-I, C-II, C-III and E are associated with those of several coagulation factors. However, whether these apolipoproteins are also associated with an increased risk of VTE remains to be established. (AU)

• Processo FAPESP: 17/09506-5 - Identificação de novos alvos para terapia anti- PCSK9: da redução da lipoproteína de baixa densidade a modulação da inflamação e coagulação
• Beneficiário: Fernanda Loureiro de Andrade Orsi
• Modalidade de apoio: Bolsas no Exterior - Pesquisa