| Full text | |
| Author(s): |
Orsi, Fernanda A.
[1, 2]
;
Lijfering, Willem M.
[2, 3]
;
Van der Laarse, Arnoud
[4, 5]
;
Ruhaak, L. Renee
[5]
;
Rosendaal, Frits R.
[2]
;
Cannegieter, Suzanne C.
[2, 6, 3]
;
Cobbaert, Christa
[5]
Total Authors: 7
|
| Affiliation: | [1] Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, Campinas, SP - Brazil
[2] Leiden Univ, Med Ctr, Dept Clin Epidemiol, POB 9600, NL-2300 RC Leiden - Netherlands
[3] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, Leiden - Netherlands
[4] Leiden Univ, Med Ctr, Dept Cardiol, Leiden - Netherlands
[5] Leiden Univ, Med Ctr, Dept Clin Chem & Lab Med, Leiden - Netherlands
[6] Leiden Univ, Med Ctr, Sect Thrombosis & Hemostasis, Dept Internal Med, Leiden - Netherlands
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | CLINICAL EPIDEMIOLOGY; v. 11, p. 625-633, 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Purpose: Apolipoproteins C-I, C-II, C-III and E have been associated with risk of arterial thrombotic diseases. We investigated whether these apolipoproteins have prothrombotic properties and are associated with risk of venous thromboembolism (VTE). Patients and methods: A total of 127 VTE patients and 299 controls were randomly selected from the Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis study (1999-2004), in the Netherlands. The apolipoproteins were quantified using mass spectrometry (LC/MS/MS), and their levels were analyzed as continuous variable (per SD increase). Results: In controls, increases in levels of apolipoproteins were associated with increases in levels of vitamin K-dependent factors, factor XI, antithrombin and clot lysis time. Additionally, increasing apolipoproteins C-III and E levels were associated with higher factor VIII and von Willebrand factor levels. Levels of C-reactive protein were not associated with any apolipoprotein. The age-and sex-adjusted odds ratios of apolipoproteins E, C-III, CII and CI to the risk of venous thrombosis were 1.21 (95% CI, 0.98-1.49), 1.19 (95% CI, 0.99-1.44), 1.24 (95% CI, 0.95-1.61) and 1.06 (95% CI, 0.87-1.30) per SD increase, respectively. These odds ratios did not attenuate after adjustments for statin use, estrogen use, BMI, alcohol use, and self-reported diabetes. Conclusions: Levels of apolipoproteins C-I, C-II, C-III and E are associated with those of several coagulation factors. However, whether these apolipoproteins are also associated with an increased risk of VTE remains to be established. (AU) | |
| FAPESP's process: | 17/09506-5 - Identification of novel targets for therapy with PCSK9: From LDL lowering to decreased inflammation and coagulation |
| Grantee: | Fernanda Loureiro de Andrade Orsi |
| Support Opportunities: | Scholarships abroad - Research |