New Cyclodepsipeptide Derivatives Revealed by Genome Mining and Molecular Networking

Autor(es)

Paulo, Bruno S. ^[1] ; Sigrist, Renata ^[1] ; Angolini, Celio F. F. ^[2] ; De Oliveira, Luciana G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Dept Organ Chem, Cidade Univ Zeferino Vaz S-N, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Fed Univ ABC UFABC, Ctr Nat & Human Sci, BR-09210580 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRYSELECT; v. 4, n. 27, p. 7785-7790, JUL 23 2019.
• Citações Web of Science: 1

Resumo

Genome mining and molecular networking analyses have revealed a renewed capacity to uncover molecules and biosynthetic pathways from bacterial secondary metabolism. The present study describes the association of genome mining and molecular networking to correlate production of valinomycin cyclodepsipeptide derivatives by Streptomyces sp. CBMAI 2042. Additionally, expression of the entire gene cluster in a heterologous host successfully allowed the association of this biosynthetic assembly to the production of montanastatin, valinomycin and at least five structural analogues, revealing a plasticity of the modules and an interesting thioesterase activity capable of assembling two or three units of the tetradepsipeptide monomer. (AU)

• Processo FAPESP: 15/01013-4 - Identificação e caracterização de uma t1PKS-transAT PKS-NRPS em Streptomyces sp. via genome mining
• Beneficiário: Renata Sigrist
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 14/12727-5 - Genome mining em Streptomyces
• Beneficiário: Luciana Gonzaga de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia
• Processo FAPESP: 13/12598-8 - Identificação de uma t1PKS-transAT PKS-NRPS em Streptomyces sp. via genome mining
• Beneficiário: Renata Sigrist
• Modalidade de apoio: Bolsas no Brasil - Mestrado