| Full text | |
| Author(s): |
Total Authors: 4
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| Affiliation: | [1] Univ Estadual Campinas, UNICAMP, Dept Organ Chem, Cidade Univ Zeferino Vaz S-N, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Fed Univ ABC UFABC, Ctr Nat & Human Sci, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 2
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| Document type: | Journal article |
| Source: | CHEMISTRYSELECT; v. 4, n. 27, p. 7785-7790, JUL 23 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Genome mining and molecular networking analyses have revealed a renewed capacity to uncover molecules and biosynthetic pathways from bacterial secondary metabolism. The present study describes the association of genome mining and molecular networking to correlate production of valinomycin cyclodepsipeptide derivatives by Streptomyces sp. CBMAI 2042. Additionally, expression of the entire gene cluster in a heterologous host successfully allowed the association of this biosynthetic assembly to the production of montanastatin, valinomycin and at least five structural analogues, revealing a plasticity of the modules and an interesting thioesterase activity capable of assembling two or three units of the tetradepsipeptide monomer. (AU) | |
| FAPESP's process: | 15/01013-4 - Mining a t1PKS-transAT PKS-NRPS in Streptomyces sp. genome |
| Grantee: | Renata Sigrist |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 14/12727-5 - Genome mining in Streptomyces |
| Grantee: | Luciana Gonzaga de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock |
| Grantee: | Arlene Gonçalves Corrêa |
| Support Opportunities: | Research Grants - Applied Research Centers Program |
| FAPESP's process: | 13/12598-8 - Mining a of t1PKS-transAT PKS-NRPS in Streptomyces sp. |
| Grantee: | Renata Sigrist |
| Support Opportunities: | Scholarships in Brazil - Master |