ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health

• Grant number: 18/24069-3
• Support type: Research Projects - Thematic Grants
• Duration: February 01, 2021 - January 31, 2026
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Principal researcher: Fernando Barbosa Júnior
• Grantee: Fernando Barbosa Júnior
• Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: Carla Barbosa Nonino ; Henrique César Santejo Silveira ; Ljubica Tasic
• Assoc. researchers: Alessandra Vincenzi Jager ; Alexandre da Costa Pereira ; Alvaro José dos Santos Neto ; Ana Carolina Bertin de Almeida Lopes ; Ana Navas-Acien ; Anderson Joel Martino Andrade ; Anderson Marliere Navarro ; Andres Dobal Campiglia ; Anthony Alexandre Weil ; Arthur Eumann Mesas ; Bruno Alves Rocha ; Carlos Roberto Bueno Júnior ; Celia Regina Nogueira ; Christian Hoffmann ; Dulce Elena Casarini ; Eduardo Purgatto ; Elisa Maria de Sousa Russo ; Gabriela de Paula Fonseca Arrifano ; Gustavo Rafael Mazzaron Barcelos ; Isabela Judith Martins Bensenor ; José Augusto Sgarbi ; Kurunthachalam Kannan ; Lilian Caroline Gonçalves de Oliveira ; Lúcia Helena Faccioli ; Marcelo Dias Baruffi ; Márcia Maria Chiquitelli Marques Silveira ; Maria Elena Crespo Lopez ; Maria Jimenez-Moreno ; Mariana de Souza Macedo ; Mariana Ragassi Urbano ; Michael Aschner ; Monica Maria Bastos Paoliello ; Patricia Helen de Carvalho Rondó ; Patrick Jeremy Parsons ; Roberto Gerardo Pellerano ; Rommel Melgaço Barbosa ; Rosa Carmen Rodríguez Martín-Doimeadios ; Shanna Helen Swan ; Sharon Reilly Kardia ; Siegfried Knasmueller ; Stefano Aurelio Bonassi ; Sylvia do Carmo Castro Franceschini ; Tiago Severo Peixe ; Torsten Plosch ; Valeria Cristina Sandrim ; Warren George Foster ; Wilson Araújo da Silva Junior ; Wilson Salgado Junior
• Associated grant(s): 21/08139-4 - Methylmercury Toxicity: A Genetic Approach, AV.EXT; 21/05059-0 - Multi-user equipment approved in grant 2018/24069-3: Inductively Coupled Plasma Mass Spectrometry (ICP-MS), AP.EMU
• Associated scholarship(s): 20/07488-2 - Impact of methylmercury (MeHg) exposure on genomic stability and biochemical parameters related to redox status, in individuals from Amazonian riverside communities chronically exposed to metal, via diet, BP.DR; 20/09557-1 - Evaluation of biomarker expression in individuals exposed to pesticides: an exposomic approach, BP.DR; 21/03633-0 - Development and application of simple and rapid analytical methods for the determination of endocrine disruptors and oxidative stress biomarkers in biological samples for evaluation of exposure of children and pregnant women, BP.PD; + associated scholarships 20/14678-2 - Study of methylmercury exposure on the expression of the DNMT1 and DNMT3A genes, and on the DNA methylation profile, in Amazonian riverside communities exposed to metal, via diet, BP.IC; 20/08687-9 - Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery, BP.PD; 20/02939-6 - Systematic analysis of the dynamic relationship between environment, metabolism, and health condition applying a machine learning approach, BP.PD - associated scholarships

Abstract

In everyday life man is exposed to a large number of compounds coming from different sources (diet, environment, the use of drugs), some are essential and others harmful to life. Most of them interact with each other and with our organism, directly or indirectly, promoting simultaneous, dynamic and complex reactions of attack and defense. This process stimulates the formation of many molecules in the human body that sustains intimate relation with the health of an individual. Also, throughout the life, this process can be modified several times, due to the dynamic change of our environment or lifestyle (ex. stress, diet modification, smoke, altered sleep, noise, physical activity, pollution), which may lead to a higher predisposition to specific pathologies. It should also be noted that these uncertain environment variables (lifestyle/diet/pollution) may anticipate specific adverse effects in some individuals due to individual genetic variations in the genome (SNPs for example) or by direct interaction with DNA (epigenome). Consequently, studies on the adverse effects of human exposure to environmental contaminants only based on the exposure relationships-effect for a single or few substances, without considering lifestyle variables are very restricted. In this sense, a new vision to investigate the relationship between environmental exposure and linked effects, that considerably expand the concept of exposure to an overall set of external (e.g. diet, supplements, water, air, drugs, social events) and internal sources (e.g. expression of proteins or generated metabolites) and defined as the exposome has been proposed. Thus, the science of exposure advanced on an Environment-Wide Association Perspective, which should exhibit a much stronger relationship with the health and disease conditions of an individual (phenotype). Thus, this project aims to establish and apply the innovative perception of exposome in Brazil (based on Environment-Wide Association Studies and Environment-Genome-Wide Association Studies). Six different plans that contemplate cross-sectional population studies: (i) PREGNANT; (ii)-AMAZOMICS; (iii)-CARDIOGENES e (iv)-ObESE; (v)-MICROPEST; (vi)-METROPOLIS are proposed as the proof-of-concept.With this in mind, patterns or profiles associated with outcomes (biomarkers of effect or specific diseases) in different Brazilian populations will be established. Thus, data obtained on the levels of toxic substances and nutrients in the body, habits, and lifestyles (diet, physical activity, stress), genomic, epigenomic, proteomic and metabolomic profiles, as well as the microbiome will be integrated by applying supervised or unsupervised data mining tools.As additional goals, the present proposal will consolidate a Brazilian research networking in human biomonitoring and exposome studies, contributing to the formation of high-quality human resources. On the other hand, the data obtained may evidence populations at risk (high exposure to contaminants and deficiency of nutrients) to public policy actions and establish molecular mechanisms that can be used to prevent (predict) future health problems. Finally, with the constant technological development (Internet of Things, IoT) and increasing use of smartphones and point-of-care systems, new intelligent apps for generating individualized external exposure data and miniaturized detection systems for biomarkers (internal exposure) can be developed, which will stimulate startup proposals (future PIPE-FAPESP projects). (AU)

Scientific publications

(31)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAVALHEIRO PAULELLI, ANA CAROLINA; CESILA, CIBELE APARECIDA; DEVOZ, PAULA PICOLI; DE OLIVEIRA, SILVANA RUELLA; BIANCHI XIMENEZ, JOAO PAULO; PEDREIRA FILHO, WALTER DOS REIS; BARBOSA JR, FERNANDO. Fundao tailings dam failure in Brazil: Evidence of a population exposed to high levels of Al, As, Hg, and Ni after a human biomonitoring study. Environmental Research, v. 205, APR 1 2022. Web of Science Citations: 0.

QUINTERO, MELISSA ESCOBAR; DE MORAES PONTES, JOAO GUILHERME; TASIC, LJUBICA. Metabolomics in degenerative brain diseases. Brain Research, v. 1773, DEC 15 2021. Web of Science Citations: 0.

BENSENOR, ISABELA M.; BARBOSA JUNIOR, FERNANDO; JANOVSKY, CAROLINA CASTRO PORTO SILVA; MARCHIONI, DIRCE; DINIZ, MARIA DE FATIMA HAUEISEN SANDER; SANTOS, ITAMAR DE SOUZA; DE ALMEIDA-PITITTO, BIANCA; SGARBI, JOSE AUGUSTO; MOLINA, MARIA DEL CARMEN B.; MILL, JOSE GERALDO; LOTUFO, PAULO A. Urinary iodine and sodium concentration and thyroid status in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 68, DEC 2021. Web of Science Citations: 0.

ESCOBAR, MELISSA QUINTERO; TASIC, LJUBICA; COSTA, TASSIA BRENA BARROSO CARNEIRO DA; STANISIC, DANIJELA; MONTALVAO, SILMARA; HUBER, STEPHANY; ANNICHINO-BIZZACCHI, JOYCE MARIA. Serum Metabolic Profiles Based on Nuclear Magnetic Resonance Spectroscopy among Patients with Deep Vein Thrombosis and Healthy Controls. METABOLITES, v. 11, n. 12 DEC 2021. Web of Science Citations: 0.

ROCHA, BRUNO A.; CESILA, CIBELE A.; MARTINS, AIRTON C.; SOUZA, MARILIA C. O.; BARBOSA JR, FERNANDO. Validation and Application of a Methodology for Quantifying Levels of Parabens in Sports Supplements from Brazil Using Liquid Chromatography-Mass Spectrometry. Journal of the Brazilian Chemical Society, DEC 2021. Web of Science Citations: 0.

NONINO, CARLA BARBOSA; NORONHA, NATALIA YUMI; DE ARAUJO FERREIRA-JULIO, MAYSA; MORIGUCHI WATANABE, LIGIA; CASSIA, KAREN FRANCISLAINE; FERREIRA NICOLETTI, CAROLINA; ROSSI WELENDORF, CAROLINE; SALGADO JUNIOR, WILSON; ROSSI SILVA SOUZA, DOROTEIA; AUGUSTA DE SOUZA PINHEL, MARCELA. Differential Expression of MMP2 and TIMP2 in Peripheral Blood Mononuclear Cells After Roux-en-Y Gastric Bypass. FRONTIERS IN NUTRITION, v. 8, OCT 13 2021. Web of Science Citations: 0.

NONINO, CARLA BARBOSA; BARATO, MARIANA; FERREIRA, FLAVIA CAMPOS; DELFINO, HEITOR BERNARDES PEREIRA; NORONHA, NATALIA YUMI; NICOLETTI, CAROLINA FERREIRA; JUNIOR, WILSON SALGADO; WELENDORF, CAROLINE ROSSI; SOUZA, DOROTEIA ROSSI SILVA; FERREIRA-JULIO, MAYSA ARAUJO; WATANABE, LIGIA MORIGUCHI; DE SOUZA PINHEL, MARCELA AUGUSTA. DRD2 and BDNF polymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery. Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity, SEP 2021. Web of Science Citations: 0.

OLIVEIRA SOUZA, MARILIA CRISTINA; ROCHA, BRUNO ALVES; OLIVEIRA SOUZA, JULIANA MARIA; JACINTO SOUZA, JOAO CARLOS; BARBOSA, FERNANDO. Levels of polybrominated diphenyl ethers in Brazilian food of animal origin and estimation of human dietary exposure. Food and Chemical Toxicology, v. 150, APR 2021. Web of Science Citations: 0.

VORMITTAG, EVANGELINA; SALDIVA, PAULO; ANASTACIO, ANDRESSA; BARBOSA, JR., FERNANDO. High levels of metals/metalloids in blood and urine of residents living in the area affected by the dam failing in Barra Longa, District, Brazil: A preliminary human biomonitoring study. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v. 83, APR 2021. Web of Science Citations: 0.

CORREIA, BANNY SILVA BARBOSA; NANI, JOAO VICTOR; WALADARES RICARDO, RANIERY; STANISIC, DANIJELA; COSTA, TASSIA BRENA BARROSO CARNEIRO; HAYASHI, MIRIAN A. F.; TASIC, LJUBICA. Effects of Psychostimulants and Antipsychotics on Serum Lipids in an Animal Model for Schizophrenia. BIOMEDICINES, v. 9, n. 3 MAR 2021. Web of Science Citations: 0.

WELENDORF, CAROLINE ROSSI; NICOLETTI, CAROLINA FERREIRA; NORONHA, NATALIA YUMI; FERREIRA, FLAVIA CAMPOS; WOLF, LETICIA SANTANA; DE SOUZA PINHEL, MARCELA AUGUSTA; PINHANELLI, VITOR CARESSATO; DE OLIVEIRA, CRISTIANA CORTES; DE OLIVEIRA, BRUNO AFFONSO PARENTI; DOS SANTOS MARTINS, LUZANIA; JUNIOR, WILSON SALGADO; NONINO, CARLA BARBOSA. The Impact of Gastric Bypass on Telomere Length and Shelterin Complex Gene Expression: 6 Months Prospective Study. OBESITY SURGERY, MAR 2021. Web of Science Citations: 0.

SANTOS-SACRAMENTO, LETICIA; ARRIFANO, GABRIELA P.; LOPES-ARAUJO, AMANDA; AUGUSTO-OLIVEIRA, MARCUS; ALBUQUERQUE-SANTOS, RAQUEL; TAKEDA, PRISCILA Y.; SOUZA-MONTEIRO, JOSE ROGERIO; MACCHI, BARBARELLA M.; DO NASCIMENTO, JOSE LUIZ M.; LIMA, RAFAEL R.; CRESPO-LOPEZ, MARIA ELENA. Human neurotoxicity of mercury in the Amazon: A scoping review with insights and critical considerations. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 208, JAN 15 2021. Web of Science Citations: 7.

CRESPO-LOPEZ, MARIA ELENA; AUGUSTO-OLIVEIRA, MARCUS; LOPES-ARAUJO, AMANDA; SANTOS-SACRAMENTO, LETICIA; TAKEDA, PRISCILA YUKI; MACCHI, BARBARELLA DE MATOS; MARTINS DO NASCIMENTO, JOSE LUIZ; MAIA, CRISTIANE S. F.; LIMA, RAFAEL R.; ARRIFANO, GABRIELA P. Mercury: What can we learn from the Amazon?. Environment International, v. 146, JAN 2021. Web of Science Citations: 6.

DE ANDRADE FREIRE, FERNANDA LAMBERT; SILVA DANTAS-KOMATSU, RAQUEL COSTA; DANTAS DE LIRA, NIETHIA REGINA; ZUZA DINIZ, ROSIANE VIANA; VIEIRA CUNHA LIMA, SEVERINA CARLA; BARBOSA JR, FERNANDO; CAMPOS PEDROSA, LUCIA FATIMA; MAURICIO SENA-EVANGELISTA, KARINE CAVALCANTI. Biomarkers of Zinc and Copper Status and Associated Factors in Outpatients with Ischemic and Non-Ischemic Heart Failure. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, JAN 2021. Web of Science Citations: 0.

VIEIRA, ALAN L.; FERREIRA, EDILENE C.; OLIVEIRA, SILVANA R.; BARBOSA, JR., FERNANDO; GOMES NETO, JOSE A. Simultaneous determination of Fe and Zn in dried blood spot by HR-CS GF AAS using solid sampling. Microchemical Journal, v. 160, n. A JAN 2021. Web of Science Citations: 0.

SILVA, ISANA RODRIGUES; FRANCISCO, LUIZA FLAVIA VEIGA; BERNARDO, CASSIA; OLIVEIRA, MARCO ANTONIO; BARBOSA, JR., FERNANDO; SILVEIRA, HENRIQUE CESAR SANTEJO. DNA methylation changes in promoter region ofCDKN2Agene in workers exposed in construction environment. BIOMARKERS, v. 25, n. 7, p. 594-602, OCT 2 2020. Web of Science Citations: 1.

OLIVEIRA SOUZA, MARILIA CRISTINA; SARAIVA, MARIA CONCEICAO PEREIRA; HONDA, MASATO; BARBIERI, MARCO ANTONIO; BETTIOL, HELOISA; BARBOSA, FERNANDO; KANNAN, KURUNTHACHALAM. Exposure to per- and polyfluorinated alkyl substances in pregnant Brazilian women and its association with fetal growth. Environmental Research, v. 187, AUG 2020. Web of Science Citations: 0.

RUEDA FURLAN, JOAO PEDRO; RODRIGUES DOS SANTOS, LUCAS DAVID; SILVA MORETTO, JESSICA APARECIDA; RAMOS, MICAELA SANTANA; LAGE GALLO, INARA FERNANDA; DIAS ALVES, GEORGIA DE ASSIS; PAULELLI, ANA CAROLINA; DE SOUZA ROCHA, CECILIA CRISTINA; CESILA, CIBELE APARECIDA; GALLIMBERTI, MATHEUS; DEVOZ, PAULA PICOLI; BARBOSA JUNIOR, FERNANDO; STEHLING, ELIANA GUEDES. Occurrence and abundance of clinically relevant antimicrobial resistance genes in environmental samples after the Brumadinho dam disaster, Brazil. Science of The Total Environment, v. 726, JUL 15 2020. Web of Science Citations: 2.

PONTELLI, REGINA C. N.; ROCHA, BRUNO A.; GARCIA, DENNY M.; PEREIRA, LEIDIANE ADRIANO; SOUZA, MARILIA C. O.; BARBOSA JR, FERNANDO; ROCHA, EDUARDO M. Endocrine disrupting chemicals associated with dry eye syndrome. OCULAR SURFACE, v. 18, n. 3, p. 487-493, JUL 2020. Web of Science Citations: 1.

ADEYEMI, JOSEPH A.; GALLIMBERTI, MATHEUS; OLISE, CHRISTIAN C.; ROCHA, BRUNO ALVES; ADEDIRE, CHRS O.; BARBOSA, FERNANDO. Evaluation of bisphenol A levels in Nigerian thermal receipts and estimation of daily dermal exposure. Environmental Science and Pollution Research, v. 27, n. 30, SI JUN 2020. Web of Science Citations: 0.

PINHEL, MARCELA A. S.; NORONHA, NATALIA Y.; NICOLETTI, CAROLINA F.; PEREIRA, VANESSA A. B.; DE OLIVEIRA, BRUNO A. P.; CORTES-OLIVEIRA, CRISTIANA; SALGADO JR, WILSON; BARBOSA, FERNANDO; MARCHINI, JULIO S.; SOUZA, DOROTEIA R. S.; NONINO, CARLA B. Changes in DNA Methylation and Gene Expression of Insulin and Obesity-Related GenePIK3R1after Roux-en-Y Gastric Bypass. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 12 JUN 2020. Web of Science Citations: 0.

ADEYEMI, JOSEPH A.; SORGI, CARLOS ARTERIO; THOMAZELA MACHADO, ANA RITA; OGUNJIMI, ABAYOMI T.; ARAUJO GARDINASSI, LUIZ GUSTAVO; NARDINI, VIVIANI; FACCIOLI, LUCIA HELENA; GREGGI ANTUNES, LUSANIA MARIA; BARBOSA JR, FERNANDO. Phospholipids modifications in human hepatoma cell lines (HepG2) exposed to silver and iron oxide nanoparticles. ARCHIVES OF TOXICOLOGY, v. 94, n. 8 MAY 2020. Web of Science Citations: 0.

XIMENEZ, JOAO PAULO B.; ZAMARIOLI, ARIANE; KACENA, MELISSA A.; BARBOSA, ROMMEL MELGACO; BARBOSA JR, FERNANDO. Association of Urinary and Blood Concentrations of Heavy Metals with Measures of Bone Mineral Density Loss: a Data Mining Approach with the Results from the National Health and Nutrition Examination Survey. BIOLOGICAL TRACE ELEMENT RESEARCH, v. 199, n. 1 APR 2020. Web of Science Citations: 1.

AZEVEDO, LARA FERREIRA; HORNOS CARNEIRO, MARIA FERNANDA; ROBERTO PORTO DECHANDT, CARLOS; CASSOLI, JULIANA SILVA; ALBERICI, LUCIANE CARLA; BARBOSA JR, FERNANDO. Global liver proteomic analysis of Wistar rats chronically exposed to low-levels of bisphenol A and S. Environmental Research, v. 182, MAR 2020. Web of Science Citations: 0.

BARBOSA, FERNANDO; ADEYEMI, JOSEPH A.; BOCATO, MARIANA ZUCCHERATO; COMAS, AHMED; CAMPIGLIA, ANDRES. A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment. Environmental Research, v. 182, MAR 2020. Web of Science Citations: 2.

ADEYEMI, JOSEPH A.; THOMAZELA MACHADO, ANA RITA; OGUNJIMI, ABAYOMI T.; ALBERICI, LUCIANE CARLA; GREGGI ANTUNES, LUSANIA MARIA; BARBOSA, JR., FERNANDO. Cytotoxicity, mutagenicity, oxidative stress and mitochondrial impairment in human hepatoma (HepG2) cells exposed to copper oxide, copper-iron oxide and carbon nanoparticles. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 189, FEB 2020. Web of Science Citations: 0.

SILVEIRA, ROMENA SANGLARD; ROCHA, BRUNO ALVES; RODRIGUES, JAIRO LISBOA; BARBOSA, JR., FERNANDO. Rapid, sensitive and simultaneous determination of 16 endocrine-disrupting chemicals (parabens, benzophenones, bisphenols, and triclocarban) in human urine based on microextraction by packed sorbent combined with liquid chromatography tandem mass spectrometry (MEPS-LC-MS/MS). Chemosphere, v. 240, FEB 2020. Web of Science Citations: 0.

MATHEUS GALLIMBERTI; BRUNO A. ROCHA; VANESSA C. O. SOUZA; ANDRES D. CAMPIGLIA; FERNANDO BARBOSA JR. Determination of Bisphenol A in Paper Products by Synchronous Fluorescence Spectroscopy and Estimation of Daily Exposure. Journal of the Brazilian Chemical Society, v. 31, n. 10, p. 2146-2154, Out. 2020. Web of Science Citations: 0.

AZEVEDO, LARA FERREIRA; PORTO DECHANDT, CARLOS ROBERTO; DE SOUZA ROCHA, CECILIA CRISTINA; HORNOS CARNEIRO, MARIA FERNANDA; ALBERICI, LUCIANE CARLA; BARBOSA JR, FERNANDO. Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food and Chemical Toxicology, v. 132, OCT 2019. Web of Science Citations: 0.

BERTIN DE ALMEIDA LOPES, ANA CAROLINA; DA CUNHA, AIRTON MARTINS; URBANO, MARIANA RAGASSI; BUZZO, MARCIA LIANE; IAKMIU CAMARGO, ALISSANA ESTER; PEIXE, TIAGO SEVERO; ASCHNER, MICHAEL; BARBOSA, FERNANDO; RIGO DA SILVA, ANA MARIA; BASTO PAOLIELLO, MONICA MARIA. Blood reference values for metals in a general adult population in southern Brazil. Environmental Research, v. 177, OCT 2019. Web of Science Citations: 0.

BOCATO, MARIANA ZUCCHERATO; BIANCHI XIMENEZ, JOAO PAULO; HOFFMANN, CHRISTIAN; BARBOSA, FERNANDO. An overview of the current progress, challenges, and prospects of human biomonitoring and exposome studies. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, v. 22, n. 5-6, p. 131-156, AUG 18 2019. Web of Science Citations: 0.