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ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health

Grant number: 18/24069-3
Support Opportunities:Research Projects - Thematic Grants
Duration: February 01, 2021 - January 31, 2026
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Fernando Barbosa Júnior
Grantee:Fernando Barbosa Júnior
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
Carla Barbosa Nonino ; Henrique César Santejo Silveira ; Ljubica Tasic
Associated researchers:Alessandra Vincenzi Jager ; Alexandre da Costa Pereira ; Alvaro José dos Santos Neto ; Ana Carolina Bertin de Almeida Lopes ; Ana Navas-Acien ; Anderson Joel Martino Andrade ; Anderson Marliere Navarro ; Andres Dobal Campiglia ; Anthony Alexandre Weil ; Arthur Eumann Mesas ; Bruno Alves Rocha ; Carlos Roberto Bueno Júnior ; Celia Regina Nogueira ; Christian Hoffmann ; Dulce Elena Casarini ; Eduardo Purgatto ; Elisa Maria de Sousa Russo ; Gabriela de Paula Fonseca Arrifano ; Gustavo Rafael Mazzaron Barcelos ; Isabela Judith Martins Bensenor ; José Augusto Sgarbi ; Kurunthachalam Kannan ; Lilian Caroline Gonçalves de Oliveira ; Lúcia Helena Faccioli ; Marcelo Dias Baruffi ; Márcia Maria Chiquitelli Marques Silveira ; Maria Elena Crespo Lopez ; Maria Jimenez-Moreno ; Mariana de Souza Macedo ; Mariana Ragassi Urbano ; Michael Aschner ; Monica Maria Bastos Paoliello ; Patricia Helen de Carvalho Rondó ; Patrick Jeremy Parsons ; Roberto Gerardo Pellerano ; Rommel Melgaço Barbosa ; Rosa Carmen Rodríguez Martín-Doimeadios ; Shanna Helen Swan ; Sharon Reilly Kardia ; Siegfried Knasmueller ; Stefano Aurelio Bonassi ; Sylvia do Carmo Castro Franceschini ; Tiago Severo Peixe ; Torsten Plosch ; Valeria Cristina Sandrim ; Warren George Foster ; Wilson Araújo da Silva Junior ; Wilson Salgado Junior
Associated grant(s):22/09989-4 - RISK ASSESSMENT OF WEATHEREED MICRO/NANOPLASTICS AND ASSOCIATED ADDITIVES AND ORGANIC CO-CONTAMINANTS, AV.EXT
21/08139-4 - Methylmercury toxicity: a genetic approach, AV.EXT
21/05059-0 - Multi-user equipment approved in grant 2018/24069-3: Inductively Coupled Plasma Mass Spectrometry (ICP-MS), AP.EMU
Associated scholarship(s):23/00226-0 - Epigenetic alterations and neurotoxic effects in Amazonian riverside populations co-exposed to lead and methylmercury and potential modulator effect of selenium and selenoenzyme genotypes, BP.PD
23/07858-2 - Organization and logistics, BP.TT
23/03780-9 - Metabonomics and Metabolomics of the exposome by NMR, BP.PD
+ associated scholarships 23/03654-3 - Development and application of simple and rapid analytical methods for the determination of endocrine disruptors and oxidative stress biomarkers in biological samples for evaluation of exposure of children and pregnant women, BP.PD
22/15068-9 - Change in the methylation pattern of genes involved in energy metabolism after bariatric surgery, BP.MS
22/10851-7 - From biomonitoring to recognition of human exposome signatures to predict risks to ongoing health, BP.TT
22/11207-4 - Preparation and Management of Database, BP.TT
22/07979-1 - Metabolomics of the exposome by Mass Spectrometry, BP.TT
22/08135-1 - From biomonitoring to recognition of human exposome signatures to predict risks to ongoing health, BP.TT
22/03933-7 - Evaluation of miRNAs profile in the search for potential biomarkers related to pesticides exposure, BP.DD
20/07488-2 - Impact of methylmercury (MeHg) exposure on genomic stability and biochemical parameters related to redox status, in individuals from Amazonian riverside communities chronically exposed to metal, via diet, BP.DR
20/09557-1 - Evaluation of biomarker expression in individuals exposed to pesticides: an exposomic approach, BP.DR
21/03633-0 - Development and application of simple and rapid analytical methods for the determination of endocrine disruptors and oxidative stress biomarkers in biological samples for evaluation of exposure of children and pregnant women, BP.PD
20/14678-2 - Study of methylmercury exposure on the expression of the DNMT1 and DNMT3A genes, and on the DNA methylation profile, in Amazonian riverside communities exposed to metal, via diet, BP.IC
20/08687-9 - Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery, BP.PD
20/02939-6 - Systematic analysis of the dynamic relationship between environment, metabolism, and health condition applying a machine learning approach, BP.PD - associated scholarships

Abstract

In everyday life man is exposed to a large number of compounds coming from different sources (diet, environment, the use of drugs), some are essential and others harmful to life. Most of them interact with each other and with our organism, directly or indirectly, promoting simultaneous, dynamic and complex reactions of attack and defense. This process stimulates the formation of many molecules in the human body that sustains intimate relation with the health of an individual. Also, throughout the life, this process can be modified several times, due to the dynamic change of our environment or lifestyle (ex. stress, diet modification, smoke, altered sleep, noise, physical activity, pollution), which may lead to a higher predisposition to specific pathologies. It should also be noted that these uncertain environment variables (lifestyle/diet/pollution) may anticipate specific adverse effects in some individuals due to individual genetic variations in the genome (SNPs for example) or by direct interaction with DNA (epigenome). Consequently, studies on the adverse effects of human exposure to environmental contaminants only based on the exposure relationships-effect for a single or few substances, without considering lifestyle variables are very restricted. In this sense, a new vision to investigate the relationship between environmental exposure and linked effects, that considerably expand the concept of exposure to an overall set of external (e.g. diet, supplements, water, air, drugs, social events) and internal sources (e.g. expression of proteins or generated metabolites) and defined as the exposome has been proposed. Thus, the science of exposure advanced on an Environment-Wide Association Perspective, which should exhibit a much stronger relationship with the health and disease conditions of an individual (phenotype). Thus, this project aims to establish and apply the innovative perception of exposome in Brazil (based on Environment-Wide Association Studies and Environment-Genome-Wide Association Studies). Six different plans that contemplate cross-sectional population studies: (i) PREGNANT; (ii)-AMAZOMICS; (iii)-CARDIOGENES e (iv)-ObESE; (v)-MICROPEST; (vi)-METROPOLIS are proposed as the proof-of-concept.With this in mind, patterns or profiles associated with outcomes (biomarkers of effect or specific diseases) in different Brazilian populations will be established. Thus, data obtained on the levels of toxic substances and nutrients in the body, habits, and lifestyles (diet, physical activity, stress), genomic, epigenomic, proteomic and metabolomic profiles, as well as the microbiome will be integrated by applying supervised or unsupervised data mining tools.As additional goals, the present proposal will consolidate a Brazilian research networking in human biomonitoring and exposome studies, contributing to the formation of high-quality human resources. On the other hand, the data obtained may evidence populations at risk (high exposure to contaminants and deficiency of nutrients) to public policy actions and establish molecular mechanisms that can be used to prevent (predict) future health problems. Finally, with the constant technological development (Internet of Things, IoT) and increasing use of smartphones and point-of-care systems, new intelligent apps for generating individualized external exposure data and miniaturized detection systems for biomarkers (internal exposure) can be developed, which will stimulate startup proposals (future PIPE-FAPESP projects). (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (58)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
STANISIC, DANIJELA; CRUZ, GUILHERME C. F.; ELIAS, LEONARDO ABDALA; TSUKAMOTO, JUNKO; ARNS, CLARICE W.; DA SILVA, DOUGLAS SOARES; MOCHKALEV, STANISLAV; SAVU, RALUCA; TASIC, LJUBICA. High-Resolution Magic-Angle Spinning NMR Spectroscopy for Evaluation of Cell Shielding by Virucidal Composites Based on Biogenic Silver Nanoparticles, Flexible Cellulose Nanofibers and Graphene Oxide. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 10, p. 10-pg., . (18/24069-3)
ASCHNER, MICHAEL; SKALNY, ANATOLY V.; MARTINS, AIRTON C.; SINITSKII, ANTON I.; FARINA, MARCELO; LU, RONGZHU; BARBOSA, FERNANDO; GLUHCHEVA, YORDANKA G.; SANTAMARIA, ABEL; TINKOV, ALEXEY A.. Ferroptosis as a mechanism of non-ferrous metal toxicity. ARCHIVES OF TOXICOLOGY, v. N/A, p. 27-pg., . (21/08139-4, 18/24069-3)
BENSENOR, ISABELA M.; BARBOSA JUNIOR, FERNANDO; JANOVSKY, CAROLINA CASTRO PORTO SILVA; MARCHIONI, DIRCE; DINIZ, MARIA DE FATIMA HAUEISEN SANDER; SANTOS, ITAMAR DE SOUZA; DE ALMEIDA-PITITTO, BIANCA; SGARBI, JOSE AUGUSTO; MOLINA, MARIA DEL CARMEN B.; MILL, JOSE GERALDO; et al. Urinary iodine and sodium concentration and thyroid status in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 68, . (15/17213-2, 18/24069-3)
DOS SANTOS, ISABELA CAMPANELLI; DA SILVA, JEFFERSON TENESSE; ROHR, PAULA; LENGERT, ANDRE VAN HELVOORT; DE LIMA, MARCOS ALVES; SILVA KAHL, VIVIAN FRANCILIA; DA SILVA, JULIANA; REIS, RUI MANUEL; SANTEJO SILVEIRA, HENRIQUE CESAR. Genomic instability evaluation by BMCyt and telomere length in Brazilian family farmers exposed to pesticides. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v. 878, p. 8-pg., . (18/24069-3)
PESSOA-LIMA, CAROLINE; TOSTES-FIGUEIREDO, JONAS; MACEDO-RIBEIRO, NATALIA; HSIOU, ANNIE SCHMALTZ; MUNIZ, FELLIPE PEREIRA; MAULIN, JOSE AUGUSTO; FRANCESCHINI-SANTOS, VINICIUS H.; DE SOUSA, FREDERICO BARBOSA; BARBOSA JR, FERNANDO; PERES LINE, SERGIO ROBERTO; et al. Structure and Chemical Composition of ca. 10-Million-Year-Old (Late Miocene of Western Amazon) and Present-Day Teeth of Related Species. BIOLOGY-BASEL, v. 11, n. 11, p. 22-pg., . (20/07997-4, 21/05059-0, 18/24069-3)
NORONHA, NATALIA YUMI; RODRIGUES, GUILHERME DA SILVA; YONEHARA NOMA, ISABELLA HARUMI; CUNHA BRANDAO, CAMILA FERNANDA; RODRIGUES, KARINE PEREIRA; BRUNO, ALEXANDRE COLELLO; SAE-LEE, CHANACHAI; WATANABE, LIGIA MORIGUCHI; DE SOUZA PINHEL, MARCELA AUGUSTA; SCHINEIDER, ISABELLE MELLO; et al. 14-weeks combined exercise epigenetically modulated 118 genes of menopausal women with prediabetes. FRONTIERS IN ENDOCRINOLOGY, v. 13, p. 15-pg., . (20/08687-9, 17/21361-2, 18/24069-3)
OLIVEIRA SOUZA, MARILIA CRISTINA; ROCHA, BRUNO ALVES; BIANCHI XIMENEZ, JOAO PAULO; DEVOZ, PAULA PICOLI; SANTANA, ANTHONY; CAMPIGLIA, ANDRES DOBAL; BARBOSA JR, FERNANDO. Urinary levels of monohydroxylated polycyclic aromatic hydrocarbons in Brazilian children and health risk assessment: a human biomonitoring-based study. Environmental Science and Pollution Research, v. 29, n. 31, p. 12-pg., . (18/24069-3, 19/07161-6, 21/03633-0)
ROHR, PAULA; DOS SANTOS, ISABELA CAMPANELLI; LENGERT, ANDRE VAN HELVOORT; DE LIMA, MARCOS ALVES; REIS, RUI MANUEL; BARBOSA JR, FERNANDO; SANTEJO SILVEIRA, HENRIQUE CESAR. Absolute telomere length in peripheral blood lymphocytes of workers exposed to construction environment. INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, v. N/A, p. 9-pg., . (18/24069-3, 12/24279-1)
NORONHA, NATALIA YUMI; BARATO, MARIANA; SAE-LEE, CHANACHAI; PINHEL, MARCELA AUGUSTA DE SOUZA; WATANABE, LIGIA MORIGUCHI; PEREIRA, VANESSA APARECIDA BATISTA; RODRIGUES, GUILHERME DA SILVA; MORAIS, DEBORAH ARAUJO; DE SOUSA, WELLINGTON TAVARES; SOUZA, VANESSA CRISTINA DE OLIVEIRA; et al. Novel Zinc-Related Differentially Methylated Regions in Leukocytes of Women With and Without Obesity. FRONTIERS IN NUTRITION, v. 9, p. 10-pg., . (18/24069-3, 20/08687-9)
VIEIRA, ALAN L.; FERREIRA, EDILENE C.; OLIVEIRA, SILVANA R.; BARBOSA, FERNANDO, JR.; GOMES NETO, JOSE A.. Simultaneous determination of Fe and Zn in dried blood spot by HR-CS GF AAS using solid sampling. Microchemical Journal, v. 160, p. 9-pg., . (19/07537-6, 18/24069-3)
WELENDORF, CAROLINE ROSSI; NICOLETTI, CAROLINA FERREIRA; NORONHA, NATALIA YUMI; FERREIRA, FLAVIA CAMPOS; WOLF, LETICIA SANTANA; DE SOUZA PINHEL, MARCELA AUGUSTA; PINHANELLI, VITOR CARESSATO; DE OLIVEIRA, CRISTIANA CORTES; DE OLIVEIRA, BRUNO AFFONSO PARENTI; DOS SANTOS MARTINS, LUZANIA; et al. The Impact of Gastric Bypass on Telomere Length and Shelterin Complex Gene Expression: 6 Months Prospective Study. OBESITY SURGERY, v. 31, n. 6, p. 8-pg., . (18/08784-4, 18/24069-3)
OLIVEIRA SOUZA, JULIANA MARIA; OLIVEIRA SOUZA, MARILIA CRISTINA; ALVES ROCHA, BRUNO; NADAL, MARTI; LUIS DOMINGO, JOSE; BARBOSA JR, FERNANDO. Levels of phthalates and bisphenol in toys from Brazilian markets: Migration rate into children's saliva and daily exposure. Science of The Total Environment, v. 828, p. 8-pg., . (18/24069-3, 15/19665-8, 14/24042-7, 19/07161-6)
VIEIRA, ALAN L.; FERREIRA, EDILENE C.; OLIVEIRA, SILVANA R.; BARBOSA, JR., FERNANDO; GOMES NETO, JOSE A.. Simultaneous determination of Fe and Zn in dried blood spot by HR-CS GF AAS using solid sampling. Microchemical Journal, v. 160, n. A, . (19/07537-6, 18/24069-3)
SANTOS-SACRAMENTO, LETICIA; ARRIFANO, GABRIELA P.; LOPES-ARAUJO, AMANDA; AUGUSTO-OLIVEIRA, MARCUS; ALBUQUERQUE-SANTOS, RAQUEL; TAKEDA, PRISCILA Y.; SOUZA-MONTEIRO, JOSE ROGERIO; MACCHI, BARBARELLA M.; DO NASCIMENTO, JOSE LUIZ M.; LIMA, RAFAEL R.; et al. Human neurotoxicity of mercury in the Amazon: A scoping review with insights and critical considerations. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 208, . (18/24069-3)
CRESPO-LOPEZ, MARIA ELENA; AUGUSTO-OLIVEIRA, MARCUS; LOPES-ARAUJO, AMANDA; SANTOS-SACRAMENTO, LETICIA; TAKEDA, PRISCILA YUKI; MACCHI, BARBARELLA DE MATOS; MARTINS DO NASCIMENTO, JOSE LUIZ; MAIA, CRISTIANE S. F.; LIMA, RAFAEL R.; ARRIFANO, GABRIELA P.. Mercury: What can we learn from the Amazon?. Environment International, v. 146, . (18/24069-3)
CESILA, CIBELE APARECIDA; SOUZA, MARILIA CRISTINA OLIVEIRA; CRUZ, JONAS CARNEIRO; BOCATO, MARIANA ZUCCHERATO; CAMPIGLIA, ANDRES DOBAL; BARBOSA, FERNANDO. Biomonitoring of polycyclic aromatic hydrocarbons in Brazilian pregnant women: Urinary levels and health risk assessment. Environmental Research, v. 235, p. 10-pg., . (19/07161-6, 22/06443-0, 18/24069-3)
BELLOT, PAULA EMILIA NUNES RIBEIRO; BRAGA, ERIK SOBRINHO; OMAGE, FOLORUNSHO BRIGHT; NUNES, FRANCISCA LEIDE DA SILVA; LIMA, SEVERINA CARLA VIEIRA CUNHA; LYRA, CLELIA OLIVEIRA; MARCHIONI, DIRCE MARIA LOBO; PEDROSA, LUCIA FATIMA CAMPOS; BARBOSA JR, FERNANDO; TASIC, LJUBICA; et al. Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications. SCIENTIFIC REPORTS, v. 13, n. 1, p. 13-pg., . (16/20054-6, 18/24069-3, 14/50867-3, 22/11207-4, 23/02691-2)
ADEYEMI, JOSEPH A.; CRUZ, JONAS C.; AYO-AWE, TOLULOPE, V; ROCHA, BRUNO A.; ADEDIRE, CHRIS O.; DE OLIVEIRA-SOUZA, VANESSA C.; OLIVEIRA SOUZA, MARILIA CRISTINA; DOMINGO, JOSE L.; BARBOSA JR, FERNANDO. Occurrence of trace elements in print paper products: Non-carcinogenic risk assessment through dermal exposure. Environmental Research, v. 237, p. 5-pg., . (18/24069-3, 22/09989-4)
NUNES RIBEIRO BELLOT, PAULA EMILIA; MOIA, MELISSA NUNES; REIS, BRUNA ZAVARIZE; CAMPOS PEDROSA, LUCIA FATIMA; TASIC, LJUBICA; BARBOSA JR, FERNANDO; MAURICIO SENA-EVANGELISTA, KARINE CAVALCANTI. Are Phosphatidylcholine and Lysophosphatidylcholine Body Levels Potentially Reliable Biomarkers in Obesity? A Review of Human Studies. MOLECULAR NUTRITION & FOOD RESEARCH, v. N/A, p. 12-pg., . (18/24069-3)
SOUZA, MARILIA CRISTINA OLIVEIRA; GONZALEZ, NEUS; HERRERO, MARTA; MARQUES, MONTSE; ROVIRA, JOAQUIM; DOMINGO, JOSE L.; BARBOSA JR, FERNANDO; NADAL, MARTI. Non-regulated aromatic amines in clothing purchased in Spain and Brazil: Screening-level exposure and health impact assessment. Journal of Environmental Management, v. 339, p. 8-pg., . (19/07161-6, 21/07994-8, 18/24069-3)
ROCHA, BRUNO ALVES; GALLIMBERTI, MATHEUS; XIMENEZ, JOAO PAULO BIANCHI; BASSO, CARLA GIOVANA; MARTINO-ANDRADE, ANDERSON JOEL; KOCH, HOLGER MARTIN; CALIXTO, LEANDRO AUGUSTO; BARBOSA, FERNANDO. An eco-friendly sample preparation procedure based on air-assisted liquid-liquid microextraction for the rapid determination of phthalate metabolites in urine samples by liquid chromatography-tandem mass spectrometry. Talanta, v. 266, p. 10-pg., . (22/07979-1, 21/03633-0, 18/24069-3, 20/02939-6)
CAMPOS, ELIDA; FREIRE, CARMEN; BARBOSA, FERNANDO; LEMOS, CRISTINA; SARACENI, VALERIA; KOIFMAN, ROSALINA J.; PINHEIRO, RAFAEL DO NASCIMENTO; DA SILVA, ILCE FERREIRA. iomonitoring of Exposure to Metals in a Population Residing in an Industrial Area in Brazil: A Feasibility Stud. NTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALT, v. 18, n. 23, . (18/24069-3)
WATANABE, LIGIA MORIGUCHI; BUENO, ANA C.; DE LIMA, LIVIA F.; FERRAZ-BANNITZ, RAFAEL; DESSORDI, RENATA; GUIMARAES, MARIANA P.; FOSS-FREITAS, MARIA C.; BARBOSA, FERNANDO; NAVARRO, ANDERSON M.. enetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statin. BRITISH JOURNAL OF NUTRITION, v. 127, n. 5, p. 679-686, . (18/24069-3, 16/05677-7)
CARDOSO, MARCELLA R.; SILVA, ALEX AP ROSINI; TALARICO, MARIA CECILIA R.; SANCHES, PEDRO H. GODOY; SFORCA, MAURICIO L.; ROCCO, SILVANA A.; REZENDE, LUCIANA M.; QUINTERO, MELISSA; COSTA, TASSIA B. B. C.; VIANA, LAIS R.; et al. Metabolomics by NMR Combined with Machine Learning to Predict Neoadjuvant Chemotherapy Response for Breast Cancer. CANCERS, v. 14, n. 20, p. 16-pg., . (18/24069-3, 19/04314-6)
BARBOSA, FERNANDO; ROCHA, BRUNO A.; SOUZA, MARILIA C. O.; BOCATO, MARIANA Z.; AZEVEDO, LARA F.; ADEYEMI, JOSEPH A.; SANTANA, ANTHONY; CAMPIGLIA, ANDRES D.. Polycyclic aromatic hydrocarbons (PAHs): Updated aspects of their determination, kinetics in the human body, and toxicity. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, v. N/A, p. 38-pg., . (18/24069-3, 19/07161-6)
OYENIYI, EMMANUEL AYOBAMI; SORGI, CARLOS ARTERIO; GARDINASSI, LUIZ GUSTAVO; AZEVEDO, LARA FERREIRA; ADEYEMI, JOSEPH ADEWUYI; OMOTOSO, OLUMUYIWA TEMITOPE; FACCIOLI, LUCIA HELENA; GREGGI ANTUNES, LUSANIA MARIA; BARBOSA JR, FERNANDO. Phospholipids modifications, genotoxic and anticholinesterase effects of pepper fruit (Dennettia tripetala G. Baker) extract in Swiss mice. Food and Chemical Toxicology, v. 165, p. 12-pg., . (18/24069-3)
ESCOBAR, MELISSA QUINTERO; TASIC, LJUBICA; COSTA, TASSIA BRENA BARROSO CARNEIRO DA; STANISIC, DANIJELA; MONTALVAO, SILMARA; HUBER, STEPHANY; ANNICHINO-BIZZACCHI, JOYCE MARIA. Serum Metabolic Profiles Based on Nuclear Magnetic Resonance Spectroscopy among Patients with Deep Vein Thrombosis and Healthy Controls. METABOLITES, v. 11, n. 12, . (18/24069-3, 16/14172-6, 18/18624-4)
SOUZA, MARILIA CRISTINA OLIVEIRA; ROCHA, BRUNO ALVES; CRUZ, JONAS CARNEIRO; PALIR, NEZA; CAMPIGLIA, ANDRES DOBAL; DOMINGO, JOSE L.; BARBOSA, FERNANDO. Risk characterization of human exposure to polycyclic aromatic hydrocarbons in vulnerable groups. Science of The Total Environment, v. 892, p. 6-pg., . (19/07161-6, 22/06443-0, 18/24069-3)
CORREIA, BANNY SILVA BARBOSA; PONTES, JOAO GUILHERME DE MORAES; NANI, JOAO VICTOR SILVA; VILLALTA, FABIAN; MOR, NATALIA CRISTINA; BORDINI, DANIELA; BRUNONI, DECIO; BRENTANI, HELENA; MARI, JAIR JESUS; HAYASHI, MIRIAN A. F.; et al. 1H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study. ACS Chemical Neuroscience, v. 14, n. 6, p. 9-pg., . (19/09207-3, 18/24069-3, 14/50867-3, 19/13112-8, 20/01107-7)
ACUNHA, TANIZE; ROCHA, BRUNO ALVES; NARDINI, VIVIANI; BARBOSA JR, FERNANDO; FACCIOLI, LUCIA HELENA. Lipidomic profiling of the Brazilian yellow scorpion venom: new insights into inflammatory responses following Tityus serrulatus envenomation. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 86, n. 9, p. 13-pg., . (15/00658-1, 21/03633-0, 18/24069-3, 14/07125-6, 22/07979-1, 18/25704-4)
OLIVEIRA, CHRISTIAN BREMMER DOS SANTOS; BARROS, ELCIO DANIEL SOUSA; DE OLIVEIRA, SILVANA RUELLA; BARBOSA, FERNANDO; VIEIRA, GERARDO MAGELA; LOPES, CICERO ALVES. Preliminary ionome of the parotoid gland secretion from Rhinella jimi toad. Toxicon, v. 225, p. 9-pg., . (18/24069-3)
NONINO, CARLA BARBOSA; NORONHA, NATALIA YUMI; DE ARAUJO FERREIRA-JULIO, MAYSA; MORIGUCHI WATANABE, LIGIA; CASSIA, KAREN FRANCISLAINE; FERREIRA NICOLETTI, CAROLINA; ROSSI WELENDORF, CAROLINE; SALGADO JUNIOR, WILSON; ROSSI SILVA SOUZA, DOROTEIA; AUGUSTA DE SOUZA PINHEL, MARCELA. Differential Expression of MMP2 and TIMP2 in Peripheral Blood Mononuclear Cells After Roux-en-Y Gastric Bypass. FRONTIERS IN NUTRITION, v. 8, . (18/24069-3, 13/12819-4)
QUINTERO, MELISSA ESCOBAR; DE MORAES PONTES, JOAO GUILHERME; TASIC, LJUBICA. Metabolomics in degenerative brain diseases. Brain Research, v. 1773, . (14/50867-3, 18/24069-3)
ROCHA, BRUNO A.; CESILA, CIBELE A.; MARTINS, AIRTON C.; SOUZA, MARILIA C. O.; BARBOSA JR, FERNANDO. Validation and Application of a Methodology for Quantifying Levels of Parabens in Sports Supplements from Brazil Using Liquid Chromatography-Mass Spectrometry. Journal of the Brazilian Chemical Society, . (18/24069-3, 21/03633-0)
CAVALHEIRO PAULELLI, ANA CAROLINA; CESILA, CIBELE APARECIDA; DEVOZ, PAULA PICOLI; DE OLIVEIRA, SILVANA RUELLA; BIANCHI XIMENEZ, JOAO PAULO; PEDREIRA FILHO, WALTER DOS REIS; BARBOSA JR, FERNANDO. Fundao tailings dam failure in Brazil: Evidence of a population exposed to high levels of Al, As, Hg, and Ni after a human biomonitoring study. Environmental Research, v. 205, . (18/24069-3)
GODOI, ALEXANDRE B.; DO CANTO, AMANDA M.; DONATTI, AMANDA; ROSA, DOUGLAS C.; BRUNO, DANIELLE C. F.; ALVIM, MARINA K.; YASUDA, CLARISSA L.; MARTINS, LUCAS G.; QUINTERO, MELISSA; TASIC, LJUBICA; et al. Circulating Metabolites as Biomarkers of Disease in Patients with Mesial Temporal Lobe Epilepsy. METABOLITES, v. 12, n. 5, p. 16-pg., . (21/04451-3, 13/07559-3, 19/00213-0, 18/24069-3, 21/04441-8, 19/00048-0, 19/25948-3, 17/26167-0)
SKALNY, ANATOLY, V; ASCHNER, MICHAEL; SEKACHEVA, MARINA, I; SANTAMARIA, ABEL; BARBOSA, FERNANDO; FERRER, BEATRIZ; AASETH, JAN; PAOLIELLO, MONICA M. B.; ROCHA, JOAO B. T.; TINKOV, ALEXEY A.. Mercury and cancer: Where are we now after two decades of research?. Food and Chemical Toxicology, v. 164, p. 11-pg., . (21/08139-4, 18/24069-3)
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