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Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery

Grant number: 20/08687-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2021
Status:Discontinued
Field of knowledge:Health Sciences - Nutrition
Principal researcher:Carla Barbosa Nonino
Grantee:Lígia Moriguchi Watanabe
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health, AP.TEM
Associated scholarship(s):21/15196-4 - Development of a polygenic risk score for predicting selenium deficiency in an admixed population, BE.EP.PD

Abstract

Selenium (Se) is an essential trace element that plays an antioxidant role mediated by selenoproteins, acting in the prevention of cardiovascular diseases and Cancer, in addition to supporting the immune system. Due to its importance for biological functions, monitoring Se concentrations is relevant, especially for patients in vulnerable health conditions. In this sense, individuals with severe Obesity undergoing Roux-en-Y gastric bypass (DGYR) stand out and may have Se deficiency both before and after surgery, with additional risks to health and life quality. In this context, the present proposal aims to identify the factors (environmental, clinical, nutritional, genetic, and referring to selenium and its metabolites) determining selenium deficiency in the postoperative period of bariatric surgery. Thus, will be evaluated in pre and postoperative period of bariatric surgery: anthropometric parameters, food consumption, biochemical parameters, serum analysis of total selenium and metabolites, other minerals, genetic profile through the analysis of single nucleotide polymorphisms and gene expression in genes related to selenium metabolism, in addition to identifying epigenetic. Finally, it will define a risk profile for Se deficiency that can assist in the classification and detection of susceptible individuals and, with that information, direct the most appropriate strategy to avoid damage to health. Statistical analysis, t/Mann-Whitney, ANOVA, Fisher/Chi-square, and Pearson/Spearman correlation tests will be applied. Specific software will analyze the raw data obtained from reading the arrays (genotyping and gene expression). A significance level of p <0.05 will be admitted. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WATANABE, LIGIA M.; NAVARRO, ANDERSON M.; SEALE, LUCIA A.. Intersection between Obesity, Dietary Selenium, and Statin Therapy in Brazil. NUTRIENTS, v. 13, n. 6, . (20/08687-9)
NONINO, CARLA BARBOSA; BARATO, MARIANA; FERREIRA, FLAVIA CAMPOS; DELFINO, HEITOR BERNARDES PEREIRA; NORONHA, NATALIA YUMI; NICOLETTI, CAROLINA FERREIRA; JUNIOR, WILSON SALGADO; WELENDORF, CAROLINE ROSSI; SOUZA, DOROTEIA ROSSI SILVA; FERREIRA-JULIO, MAYSA ARAUJO; et al. DRD2 and BDNF polymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery. Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity, . (18/08784-4, 20/08687-9, 13/12819-4, 18/24069-3)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.