Challenging Aspects to Precise Health Strategies in Native Hawaiian and Other Pacific Islanders Using Statins

Author(s)

Watanabe, Ligia M. ; Seale, Lucia A.

• Document type: Journal article
• Source: FRONTIERS IN PUBLIC HEALTH; v. 10, p. 6-pg., 2022-02-28.

Abstract

Cardiometabolic disorders (CD), including cardiovascular disease (CVD), diabetes, and obesity, are the leading cause of health concern in the United States (U.S.), disproportionately affecting indigenous populations such a Native Hawaiian and Other Pacific Islanders (NHOPI). Dyslipidemia, a prevalent risk factor for the development and progression of CVD, is more prone to occur in NHOPI than other populations in the U.S. High-intensity statin therapy to reduce low-density lipoprotein cholesterol is associated with the prevention of CVD events. However, significant side-effects, such as muscle disorders, have been associated with its use. Different ethnic groups could experience variation in the prevalence of statin side effects due to sociodemographic, behavioral, and/or biological factors. Therefore, identifying the most impactful determinants that can be modified to prevent or reduce statin side effects for individuals from high-risk ethnic minority groups, such as NHOPI, can lead to more effective strategies to reduce health disparities. Thus, our Mini-Review explores the challenging aspects of public health precise strategies in NHOPI taking statins, including a culturally informed additional therapy that could positively impact the NHOPI population. (AU)

• FAPESP's process: 20/08687-9 - Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery
• Grantee: Lígia Moriguchi Watanabe
• Support Opportunities: Scholarships in Brazil - Post-Doctoral