Identification of genetic polymorphisms with impact on weight change and biochemical characteristics of obese individuals after gastric bypass Roux-Y

• Grant number: 12/05539-2
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2012
• End date: June 30, 2014
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Carla Barbosa Nonino
• Grantee: Carla Barbosa Nonino
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Obesity is considered one of the most serious public health problems of modern society, and the positive energy balance due to increased energy intake and reduced physical activity contributes significantly to the epidemic of obesity. However, this disease is complex and involves genetic, behavioral and environmental factors. Studies show genetic influence on body mass between 30 and 70% and identified 127 possible genes associated with obesity. Research aimed to find interactions between genes and environment allowed the identification of single nucleotide polymorphisms (SNPs) that may influence individuals' responses to food. Considering the low efficacy of clinical treatment for grade III obese patients, the number of bariatric surgeries performed has greatly increased in recent decades. The surgery promotes weight loss and significant improvement / resolution of comorbidities such as diabetes mellitus, dyslipidemia and hypertension. However, maintenance of weight lost is difficult to reach, and many patients have regained weight in the late postoperative period. However, regardless of the strategy used in the control / treatment of obesity, the individual response to interventions is highly variable. Some studies suggest that genetic variation among individuals may explain the variety of physiological responses existing in the same environment, explaining why some individuals are more likely to win / lose weight than others in the same environmental conditions. There are few studies evaluating the role of bariatric surgery as a treatment for obesity and its association with the different genes involved in obesity. However, these studies may elucidate the mechanisms associated with weight loss, for maintaining weight loss and the most appropriate treatment for different individuals. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NICOLETTI, CAROLINA FERREIRA; RUS PEREZ DE OLIVEIRA, ANA PAULA; FRANCO BROCHADO, MARIA JOSE; DE OLIVEIRA, BRUNO PARENTI; DE SOUZA PINHEL, MARCELA AUGUSTA; MARCHINI, JULIO SERGIO; DOS SANTOS, JOSE ERNESTO; SALGADO JUNIOR, WILSON; SILVA JUNIOR, WILSON ARAUJO; NONINO, CARLA BARBOSA. UCP1-3826 A > G polymorphism affects weight, fat mass, and risk of type 2 diabetes mellitus in grade III obese patients. NUTRITION, v. 32, n. 1, p. 83-87, JAN 2016. (12/05539-2, 12/03623-6)

NICOLETTI, C. F.; KIMURA, B. M.; DE OLIVEIRA, B. A. P.; DE PINHEL, M. A. S.; SALGADO, W.; MARCHINI, J. S.; NONINO, C. B.. Role of UCP2 polymorphisms on dietary intake of obese patients who underwent bariatric surgery. CLINICAL OBESITY, v. 6, n. 5, p. 354-358, OCT 2016. (12/05539-2, 12/03623-6)

NICOLETTI, CAROLINA F.; DE OLIVEIRA, ANA PAULA R. P.; BROCHADO, MARIA JOSE F.; PINHEL, MARCELA A. S.; DE OLIVEIRA, BRUNO A. P.; MARCHINI, JULIO S.; DOS SANTOS, JOSE E.; SALGADO, JR., WILSON; CURY, NATHALIA MORENO; DE ARAUJO, LUIZA FERREIRA; et al. The Ala55Val and-866G > A polymorphisms of the UCP2 gene could be biomarkers for weight loss in patients who had Roux-en-Y gastric bypass. NUTRITION, v. 33, p. 326-330, JAN 2017. (12/05539-2, 12/03623-6)

NICOLETTI, CAROLINA FERREIRA; SOUZA PINHEL, MARCELA A.; PARENTI DE OLIVEIRA, BRUNO AFFONSO; MARCHINI, JULIO SERGIO; SALGADO JUNIOR, WILSON; SILVA JUNIOR, WILSON ARAUJO; NONINO, CARLA BARBOSA. The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass. Journal of Nutrigenetics and Nutrigenomics, v. 9, n. 5-6, p. 222-230, 2016. (12/05539-2, 12/03623-6)