DRD2 and BDNF polymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery

Author(s):Show less -

Nonino, Carla Barbosa ^[1] ; Barato, Mariana ^[2] ; Ferreira, Flavia Campos ^[1] ; Delfino, Heitor Bernardes Pereira ^[1] ; Noronha, Natalia Yumi ^[1] ; Nicoletti, Carolina Ferreira ^[1] ; Junior, Wilson Salgado ^[3] ; Welendorf, Caroline Rossi ^[1] ; Souza, Doroteia Rossi Silva ^[2] ; Ferreira-Julio, Maysa Araujo ^[2] ; Watanabe, Ligia Moriguchi ^[1] ; de Souza Pinhel, Marcela Augusta ^{[2, 1]}

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, Lab Nutrigenom Studies, FMRP USP, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Sao Jose do Rio Preto Med Sch, Dept Mol Biol, Sao Jose Do Rio Preto, SP - Brazil

^[3] Ribeirao Preto Med Sch, Dept Surg & Anat, Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity; SEP 2021.
• Web of Science Citations: 0

Abstract

Aim The aim of this study was to analyze the association and susceptibility of Single Nucleotide Polymorphisms (SNPs) in the DRD2 and BDNF genes with BED in patients with weight regain in the postoperative period of bariatric surgery. Methods One hundred and seventy-seven individuals who underwent bariatric surgery with weight regain were evaluated and divided into two groups according to the BED diagnostic. The individuals were submitted to an anthropometric evaluation, analysis of the presence of BED using a validated questionnaire, and blood collection for genotyping of the polymorphisms rs6265 (BDNF) and rs1800497 (DRD2) by real-time polymerase chain reaction (RT-PCR). Results The presence of wild-type alleles for rs1800497 (CC) and rs6265 (GG) was more frequent in patients without BED. Nevertheless, the presence of one or two variant alleles for rs1800497 (CT + TT) and rs6265 (GA + AA) was more frequent in patients with BED. The combination of the two studied SNPs prevailed in patients with BED. Conclusions The presence of allele frequency of rs1800497 SNP in the DRD2 gene and rs6265 SNP in the BDNF gene, isolated and/or combined, indicated an additional risk for the development of BED in patients with obesity, especially in the context of weight regain. (AU)

• FAPESP's process: 18/08784-4 - Weight regain in the postoperative period of bariatric surgery: sociodemographic, clinical, nutritional and genetic contributions
• Grantee: Carla Barbosa Nonino
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/08687-9 - Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery
• Grantee: Lígia Moriguchi Watanabe
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/12819-4 - Genetic, clinical, biochemical and heart rate variability changes in grade III Obesity pre and post bariatric surgery
• Grantee: Marcela Augusta de Souza Pinhel
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health
• Grantee: Fernando Barbosa Júnior
• Support Opportunities: Research Projects - Thematic Grants