Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intersection between Obesity, Dietary Selenium, and Statin Therapy in Brazil

Full text
Author(s):
Watanabe, Ligia M. [1] ; Navarro, Anderson M. [1] ; Seale, Lucia A. [2]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Hlth Sci, Div Nutr & Metab, BR-14040900 Ribeirao Preto, SP - Brazil
[2] Univ Hawaii Manoa, Pacific Biosci Res Ctr, Sch Ocean & Earth Sci & Technol, Honolulu, HI 96822 - USA
Total Affiliations: 2
Document type: Review article
Source: NUTRIENTS; v. 13, n. 6 JUN 2021.
Web of Science Citations: 0
Abstract

Obesity is among the most alarming health concerns, impacting public health and causing a socioeconomic challenge, especially in developing countries like Brazil, where approximately one quart of the population presents obesity. As an established risk factor for numerous comorbidities with a multifactorial etiology, obesity is a consequence of energy-dense overfeeding, however with significant undernourishment, leading to excessive adipose tissue accumulation and dysfunction, dyslipidemia, and micronutrient deficiencies. About 60% of patients with obesity take statins, a cholesterol-lowering medication, to curb dyslipidemia, with similar to 10% of these patients presenting various myopathies as side effects. Statins act upon the rate-limiting enzyme of cholesterol biosynthesis in the liver, which is a pathway providing intermediates to the synthesis of selenoproteins, i.e., enzymes containing the micronutrient selenium. Statins have been postulated to negatively impact selenoprotein synthesis, particularly in conditions of selenium deficiency, and potentially implicated in the myopathies occurring as side effects of statins. The Brazilian population is prone to selenium deficiency, hence could be considered more susceptible to statin side effects. This review examines the specific consequences to the Brazilian population of the harmful intersection between obesity development and concomitant micronutrient deficiencies, particularly selenium, combined with statin treatment in the context of nutrition in Brazil. (AU)

FAPESP's process: 20/08687-9 - Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery
Grantee:Lígia Moriguchi Watanabe
Support Opportunities: Scholarships in Brazil - Post-Doctoral