Intersection between Obesity, Dietary Selenium, and Statin Therapy in Brazil

Autor(es)

Watanabe, Ligia M. ^[1] ; Navarro, Anderson M. ^[1] ; Seale, Lucia A. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Hlth Sci, Div Nutr & Metab, BR-14040900 Ribeirao Preto, SP - Brazil

^[2] Univ Hawaii Manoa, Pacific Biosci Res Ctr, Sch Ocean & Earth Sci & Technol, Honolulu, HI 96822 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: NUTRIENTS; v. 13, n. 6 JUN 2021.
• Citações Web of Science: 0

Resumo

Obesity is among the most alarming health concerns, impacting public health and causing a socioeconomic challenge, especially in developing countries like Brazil, where approximately one quart of the population presents obesity. As an established risk factor for numerous comorbidities with a multifactorial etiology, obesity is a consequence of energy-dense overfeeding, however with significant undernourishment, leading to excessive adipose tissue accumulation and dysfunction, dyslipidemia, and micronutrient deficiencies. About 60% of patients with obesity take statins, a cholesterol-lowering medication, to curb dyslipidemia, with similar to 10% of these patients presenting various myopathies as side effects. Statins act upon the rate-limiting enzyme of cholesterol biosynthesis in the liver, which is a pathway providing intermediates to the synthesis of selenoproteins, i.e., enzymes containing the micronutrient selenium. Statins have been postulated to negatively impact selenoprotein synthesis, particularly in conditions of selenium deficiency, and potentially implicated in the myopathies occurring as side effects of statins. The Brazilian population is prone to selenium deficiency, hence could be considered more susceptible to statin side effects. This review examines the specific consequences to the Brazilian population of the harmful intersection between obesity development and concomitant micronutrient deficiencies, particularly selenium, combined with statin treatment in the context of nutrition in Brazil. (AU)

• Processo FAPESP: 20/08687-9 - Deficiência de selênio: identificação de um perfil de risco considerando fatores genéticos, clínicos e ambientais de pacientes com Obesidade no pré e pós-operatório da cirurgia bariátrica
• Beneficiário: Lígia Moriguchi Watanabe
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado