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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

High-fat diet intake induces depressive-like behavior in ovariectomized rats

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Autor(es):
Boldarine, Valter T. [1] ; Pedroso, Amanda P. [1] ; Neto, Nelson I. P. [1] ; Dornellas, Ana P. S. [1] ; Nascimento, Claudia M. O. [1] ; Oyama, Lila M. [1] ; Ribeiro, Eliane B. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 9, JUL 22 2019.
Citações Web of Science: 1
Resumo

This study tested the effects of ovariectomy, allied or not to high-fat feeding and estradiol replacement, on hormonal, metabolic and behavioral parameters, to explore the connection of obesity and depression after menopause. Wistar rats were either ovariectomized or sham-operated and fed with either standard chow or lard-enriched diet for twelve weeks. Sub-groups of ovariectomized rats received estradiol replacement. Depressive-like behaviors were assessed by the forced swim test and locomotor activity was assessed by the elevated plus maze test. Ovariectomy alone increased body weight gain and feed efficiency and induced hyperleptinemia and glucose intolerance while it increased caloric intake and body adiposity only marginally. High-fat intake alone induced obesity and, in combination with ovariectomy, accentuated the ovariectomy-induced alterations. Estradiol replacement attenuated the hormonal alterations only in chow-fed rats. Ovariectomy combined with high-fat intake induced depressive-like behaviors, which were marginally attenuated by estradiol. Depressive-like behaviors were associated with metabolic and body composition parameters and with estrogen status. The data indicate that the vulnerability to develop depression after menopause is influenced by high-fat intake. It is suggested that weight management is a crucial issue in postmenopausal women, probably having a beneficial role in preventing the appearance of mental health problems. (AU)

Processo FAPESP: 12/03172-4 - Obesidade e depressão na pós-menopausa: estudo em ratas dos efeitos da ovariectomia sobre aspectos comportamentais e da regulação central da ingestão alimentar
Beneficiário:Eliane Beraldi Ribeiro
Modalidade de apoio: Auxílio à Pesquisa - Regular