| Texto completo | |
| Autor(es): |
Telles-Longui, Milena
[1]
;
Mourelle, Danilo
[1]
;
Schowe, Natalia Mendes
[2, 1]
;
Cipolli, Gabriela Cabett
[3]
;
Malerba, Helena Nascimento
[2, 1]
;
Buck, Hudson Sousa
[2, 4]
;
Viel, Tania Araujo
[3, 1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Biomed Sci, Grad Course Pharmacol, Sao Paulo - Brazil
[2] Res Grp Neuropharmacol Aging, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil
[4] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | British Journal of Pharmacology; v. 176, n. 17 JULY 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Background and Purpose Attention training reverses the neurodegeneration and memory loss promoted by infusion of amyloid-beta (A beta) peptide in rats and increases the density of alpha 7 nicotinic ACh receptors (alpha 7nAChRs) in brain areas related to memory. Hence, we aimed to assess the role of alpha 7nAChRs in the memory recovery promoted by attention training. Experimental Approach C57Bl/6 mice were chronically infused with A beta, A beta plus the alpha 7 antagonist methyllycaconitine (MLA), or MLA alone. Control animals were infused with vehicle. Animals were subjected weekly to the active avoidance shuttle box for 4 weeks (attention training). The brain and serum were collected for biochemical and histological analysis. Key Results A beta caused cognitive impairment, which was reversed by the weekly training, whereas A beta + MLA also promoted memory loss but with no reversal with weekly training. MLA alone also promoted memory loss but with only partial reversal with the training. Animals infused with A beta alone showed senile plaques in hippocampus, no change in BDNF levels in cortex, hippocampus, and serum, but increased AChE activity in cortex and hippocampus. Co-treatment with MLA increased AChE activity and senile plaque deposition in hippocampus as well as reducing BDNF in hippocampus and serum, suggesting a lack of alpha 7nAChR function leads to a loss of neuroprotection mechanisms. Conclusions and Implications The alpha 7nAChR has a determinant role in memory recovery and brain resilience in the presence of neurodegeneration promoted by A beta peptide. These data support further studies concerning these receptors as pharmacological targets for future therapies. (AU) | |
| Processo FAPESP: | 13/06935-1 - Avaliação de alterações em placas senis e marcadores colinérgicos no cérebro de camundongos submetidos a um modelo de neurodegeneração, após treino de atenção. |
| Beneficiário: | Gabriela Cabett Cipolli |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 16/20574-0 - Avaliação da efetividade do tratamento com microdoses de litio, combinado ou não com ambiente enriquecido, para o envelhecimento saudável. |
| Beneficiário: | Helena Nascimento Malerba |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 12/12917-3 - Estudo das alterações moleculares colinérgicas que ocorrem após a aplicação de estratégias não-farmacológicas para melhora da memória |
| Beneficiário: | Tânia Araújo Viel |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/07365-9 - Avaliação da função de receptores nicotínicos alfa7 na manutenção da memória de camundongos após indução de neurodegeneração. |
| Beneficiário: | Milena Telles |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 16/07115-6 - Estudo translacional de estratégias e biomarcadores para a promoção da longevidade saudável |
| Beneficiário: | Tânia Araújo Viel |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |