Genetic background of CTX-M-15-producing Enterobacter hormaechei ST114 and Citrobacter freundii ST265 co-infecting a free-living green turtle (Chelonia mydas)

Autor(es)

Goldberg, Daphne W. ^[1] ; Fernandes, Miriam R. ^[2] ; Sellera, Fabio P. ^[3] ; Costa, Daniela G. C. ^[4] ; Loureiro Bracarense, Ana Paula ^[5] ; Lincopan, Nilton ^{[6, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Londrina, Postgrad Program Anim Sci, Dept Vet Prevent Med, Londrina - Brazil

^[2] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Internal Med, Sch Vet Med & Anim Sci, Sao Paulo - Brazil

^[4] Pro Tamar Fdn, Ubatuba, SP - Brazil

^[5] Univ Estadual Londrina, Lab Anim Pathol, Vet Med Dept, Londrina - Brazil

^[6] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ZOONOSES AND PUBLIC HEALTH; v. 66, n. 5, p. 540-545, AUG 2019.
• Citações Web of Science: 0

Resumo

CTX-M-type extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae have become identified in marine ecosystem constituting a serious ecological issue. In this respect, although contamination of coastal waters and seafood, and even colonization of seabirds and fishes have been increasingly reported, molecular data are lacking to elucidate the clinical impact of ESBL producers in infected marine animals. In this study, using a genomic approach, we have analysed the genetic background of CTX-M-15-producing Enterobacter hormaechei (belonging to the international human clone ST114) and Citrobacter freundii (ST265) co-infecting a free-living green turtle (Chelonia mydas) suffering from septic arthritis, which progressed to generalized coelomitis and death. Wide resistome of these pathogens contributed to treatment failure and death of the animal. (AU)

• Processo FAPESP: 15/13527-2 - Relação ancestral, pan-resistoma plasmidial de Escherichia coli produtora de b-lactamases de espectro estendido (CTX-M) e métodos de cura plasmidial
• Beneficiário: Miriam Rodriguez Fernandes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/08593-9 - Pan-resistoma de Klebsiella pneumoniae e Escherichia coli produtoras de beta-lactamases (KPC-2, CTX-M-8, CTX-M-15) endêmicas no Brasil
• Beneficiário: Nilton Erbet Lincopan Huenuman
• Modalidade de apoio: Auxílio à Pesquisa - Regular