Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Subtyping of plasmid-mediated quinolone resistance among Salmonella serotypes by whole genome sequencing

Texto completo
Autor(es):
Soares, Flavia Barrosa [1] ; Camargo, Carlos Henrique [1] ; Vieira Cunha, Marcos Paulo [2] ; de Almeida, Elisabete Aparecida [1] ; de Jesus Bertani, Amanda Maria [1] ; de Carvalho, Eneas [3] ; de Paiva, Jacqueline Boldrin [4] ; Fernandes, Sueli Aparecida [1] ; Tiba-Casas, Monique Ribeiro [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Adolfo Lutz Inst, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Vet Med, Sao Paulo - Brazil
[3] Butantan Inst, Sao Paulo - Brazil
[4] BioCamp, Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 94, n. 4, p. 403-406, AUG 2019.
Citações Web of Science: 0
Resumo

Most known plasmids are identified by conferring virulence or antimicrobial resistance phenotypes and such characteristics aid in the success of the dispersion of different plasmid types between bacteria from different sources. This study aimed to perform the subtyping of the plasmid-mediated quinolone resistance, detected in Salmonella spp. A total of 34 Salmonella strains non-susceptible to ciprofloxacin were evaluated. Strains were selected based on the presence of PMQR determined by Polymerase Chain Reaction and further submitted to Next Generation Sequencing. Most of the strains presented the qnrB19 in small ColE-like plasmids and qnrB2 gene associated with IncN/ST5 plasmids also detected. Our results indicated the co-occurrence of PMQR and ESBLs in plasmids that are a lineage of epidemic plasmids circulating in Salmonella in which additional resistances were detected, highlighting the potential threat of resistance Salmonella to public health, particularly in infections in which antimicrobial therapy is needed. (C) 2019 Published by Elsevier Inc. (AU)

Processo FAPESP: 16/18221-1 - Subtipagem molecular de plasmídeos carreando genes mediadores de resistência a quinolonas em cepas de Salmonella spp
Beneficiário:Monique Ribeiro Tiba Casas
Linha de fomento: Auxílio à Pesquisa - Regular