Shortening telomere is associated with subclinical atherosclerosis biomarker in omnivorous but not in vegetarian healthy men

Autor(es)

Cinegaglia, Naiara ^[1] ; Antoniazzi, Luiza ^[2] ; Rosa, Daniela ^[3] ; Miranda, Debora ^[3] ; Acosta-Navarro, Julio ^[2] ; Bortolotto, Luiz ^[2] ; Hong, Valeria ^[2] ; Sandrim, Valeria ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ IBB UNESP, Inst Biosci, Botucatu, SP - Brazil

^[2] Univ Sao Paulo, Med Sch, Heart Inst InCor, Sao Paulo - Brazil

^[3] Univ Fed Minas Gerais, Med Sch, Lab Mol Med, UFMG, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AGING-US; v. 11, n. 14, p. 5070-5080, JUL 31 2019.
• Citações Web of Science: 0

Resumo

Telomere length is considered to be a biomarker of biological aging and age-related disease. There are few studies that have evaluated the association between telomere length and diet, and none of them have evaluated the impact of a vegetarian diet on telomere length and its correlation with cardiovascular biomarkers in apparently healthy subjects. Therefore, our objectives were to evaluate leukocyte telomere length (LTL) in vegetarians and omnivorous subjects and its association with classical cardiovascular risk biomarkers. From the total of 745 participants initially recruited, 44 omnivorous and 44 vegetarian men apparently healthy were selected for this study and LTL was measured in 39 omnivorous and 41 vegetarians by Real-Time Quantitative PCR reaction. Although telomere length was not different between omnivorous and vegetarians, we found a strong negative correlation between LTL and IMT (intima-media thickness) in omnivorous, but not in vegetarian group. In addition, omnivorous who were classified with short telomere length had higher carotid IMT compared to vegetarians. Our data suggest that telomere length can be a marker of subclinical atherosclerosis in the omnivorous group. (AU)

• Processo FAPESP: 15/20669-8 - Comparação de padrões de dieta vegetariana versus onívora sobre o efeito de ativação da via NRF2 em células endoteliais
• Beneficiário: Naiara da Costa Cinegaglia
• Modalidade de apoio: Bolsas no Brasil - Doutorado