Sex differences and the role of ovarian hormones in site-specific nociception of SHR

Autor(es)

Santos, Bruna M. ^[1] ; Nascimento, Glance C. ^[2] ; Capel, Camila P. ^[2] ; Borges, Gabriela S. ^[1] ; Rosolen, Thales ^[2] ; Sabino, Joao P. J. ^[3] ; Leite-Panissi, Christie R. A. ^[4] ; Branco, Luiz G. S. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Dent Fac, Dept Morphol Physiol & Basic Pathol, Ribeirao Preto, SP - Brazil

^[3] Univ Fed Piaui, Dept Biophys & Physiol, Teresina, Piaui - Brazil

^[4] Univ Sao Paulo, Sch Philosophy Sci & Literature Ribeirao Preto, Psychobiol Grad Program, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 317, n. 2, p. R223-R231, AUG 2019.
• Citações Web of Science: 0

Resumo

Accurate diagnosis and treatment of pain is dependent on knowledge of the variables that might alter this response. Some of these variables are the locality of the noxious stimulus, the sex of the individual, and the presence of chronic diseases. Among these chronic diseases, hypertension is considered a serious and silent disease that has been associated with hypoalgesia. The main goal of this study was to evaluate the potential nociceptive differences in spontaneously hypertensive rats (SHR) regarding the locality of the stimulus, i.e., the temporomandibular joint or paw, the sex, and the role of ovarian hormones in a model of mechanical nociception (Von Frey test) or formalin-induced inflammatory nociception. Our results indicate that SHR had lower orofacial mechanical nociception beyond the lower mechanical nociception in the paw compared with WKY rats. In a model of formalin-induced inflammatory nociception, SHR also had decreased nociception compared with normotensive rats. We also sought to evaluate the influence of sex and ovarian hormones on orofacial mechanical nociception in SHR. We observed that female SHR had higher mechanical nociception than male SHR only in the paw, but it had higher formalin-induced orofacial nociception than male SHR. Moreover, the absence of ovarian hormones caused an increase in mean arterial pressure and a decrease in paw nociception in female SHR. (AU)

• Processo FAPESP: 17/03645-3 - Papel do sulfeto de hidrogênio na modulação de alodinia orofacial em modelo experimental de hipertensão arterial
• Beneficiário: Camila Porto Capel
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 16/09364-3 - Papel do sulfeto de hidrogênio endógeno na área preóptica modulando a tolerância ao LPS.
• Beneficiário: Bruna Maitan Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/17681-9 - Alterações fisiopatológicas durante a inflamação sistêmica
• Beneficiário: Luiz Guilherme de Siqueira Branco
• Modalidade de apoio: Auxílio à Pesquisa - Temático