Low-dose in utero exposure to finasteride promotes developmental changes in both male and female gerbil prostates

Autor(es)

Maldarine, Juliana S. ^[1] ; Sanches, Bruno D. A. ^[1] ; Santos, Vitoria A. ^[2] ; Amaro, Gustavo M. ^[2] ; Calmon, Marilia F. ^[3] ; Rahal, Paula ^[3] ; Goes, Rejane M. ^[2] ; Vilamaior, Patricia S. L. ^[2] ; Taboga, Sebastiao R. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Sao Paulo - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Biol, Lab Microscopy & Microanal, Sao Paulo - Brazil

^[3] Sao Paulo State Univ UNESP, Dept Biol, Lab Genome Studies, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ENVIRONMENTAL TOXICOLOGY; v. 35, n. 1 AUG 2019.
• Citações Web of Science: 1

Resumo

The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to inhibit the conversion of testosterone in its most active form, dihydrotestosterone. It is known that intrauterine exposure to finasteride causes changes in the male prostate even at low dosages; however, it is not known whether these dosages are capable of causing changes in the female prostate, which is present in a large number of mammalian species, including humans. In the present study, histochemistry, immunohistochemistry, immunofluorescence, serological dosages, and three-dimensional reconstruction techniques were employed to evaluate the effects of intrauterine exposure to a low dose of finasteride (100 mu g.BW/d) on postnatal prostate development in male and female Mongolian gerbils. The results indicate that the gerbil female prostate also undergoes alterations following intrauterine exposure to finasteride, exhibiting a thickening of periductal smooth muscle and increased stromal proliferation. There are also intersex differences in the impact of exposure on the expression of the androgen receptor, which was increased in males, and of the estrogen-alpha receptor, which was decreased in the male prostate but unchanged in females. Altogether, this study indicates there are sex differences in the effects of finasteride exposure even at low dosages. (AU)

• Processo FAPESP: 13/15939-0 - Avaliação da exposição estrogênica intra-uterina sobre as principais vias de interações epitélio-mesenquimais envolvidas na morfogênese das ramificações do lobo ventral da próstata do Gerbilo da Mongólia (Meriones unguiculatus)
• Beneficiário: Bruno Domingos Azevedo Sanches
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 16/16509-8 - Avaliação dos efeitos da finasterida sobre o desenvolvimento prostático intrauterino e pós-natal inicial no gerbilo da Mongólia (Meriones unguiculatus)
• Beneficiário: Juliana dos Santos Maldarine
• Modalidade de apoio: Bolsas no Brasil - Mestrado