Emergent multidrug-resistant nontyphoidal Salmonella serovars isolated from poultry in Brazil coharboring bia(CTX-M-2) and qnrB or bla(CMY-2) in large plasmids

Autor(es)

Casarin Penha Filho, Rafael Antonio ^[1] ; Ferreira, Joseane Cristina ^[2] ; Iba Kanashiro, Ana Maria ^[3] ; Junior, Angelo Berchieri ^[1] ; da Costa Darini, Ana Lucia ^[2]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Agr & Vet Sci, BR-14884900 Jaboticabal, SP - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[3] Inst Biol Descalvado, BR-13690000 Descalvado, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 95, n. 1, p. 93-98, SEP 2019.
• Citações Web of Science: 0

Resumo

The number of foodborne gastroenteritis caused by nontyphoidal Salmonella (NTS) worldwide is estimated to be 80.3 million each year. Currently, antimicrobial-resistant NTS disseminated in the animal environment increases the risk of aggravated foodborne outbreaks. Poultry are important source of foodborne NTS infections. This study was conducted to evaluate the phenotypic and genotypic characteristics of 83 NTS isolates from poultry, classified within 36 different serovars. The most prevalent serovar was S. Schwarzengrund (10/83), from which 8/10 were multidrug resistant (MDR). The antimicrobial susceptibility testing showed a total of 18 MDR isolates, from which 8/18 coharbored bla(CTX-M-2) and qnrB5. The genes qnrB5, bla(CRX-M-2), qnrB2, or bla(CMY-2) were also found alone in other MDR isolates. All resistance genes were harbored in large plasmids, ranging from 30 to 270 kb. The pColE replicon was present in 8 MDR isolates; however it was not associated with resistance. ISCR1 and class I integron structures were always associated with bla(CTX-M-2). (C) 2019 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 17/00620-0 - Avaliação do potencial vacinal de proteínas recombinantes para proteção contra Salmonella enterica e do uso de citocinas de aves (Gallus gallus) como adjuvantes e imunoterápicos
• Beneficiário: Rafael Antonio Casarin Penha Filho
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 16/12293-0 - Avaliação do potencial vacinal de proteínas recombinantes para proteção contra Salmonella enterica e do uso de citocinas de aves (Gallus gallus) como adjuvantes e imunoterápicos
• Beneficiário: Rafael Antonio Casarin Penha Filho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 14/14494-8 - Epidemiologia molecular de bactérias gram-negativas e genética da resistência a antibióticos
• Beneficiário: Ana Lúcia da Costa Darini
• Modalidade de apoio: Auxílio à Pesquisa - Temático