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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Low-fat and fat-free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature

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Autor(es):
Rocha, Audrey F. L. [1] ; Miotto, Larissa N. [1] ; Ferrisse, Tulio M. [1] ; Silveira, Heitor A. [1] ; Almeida, Luciana Y. [2, 3] ; Bufalino, Andreia [1] ; Navarro, Claudia M. [1] ; Leon, Jorge E. [4]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Araraquara Dent Sch, Oral Med, Dept Diag & Surg, Sao Paulo - Brazil
[2] Univ Sao Paulo, FMRP, Ribeirao Preto Med Sch, Dept Internal Med, Hematology Div, Sao Paulo - Brazil
[3] Univ Sao Paulo, FMRP, Ribeirao Preto Med Sch, Dept Internal Med, Clin OncolDiv, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Stomatol Publ Oral Hlth & Forens Dent, Ribeirao Preto Dent Sch, Oral Pathol, FORP, Ave Cafe S-N, BR-14040904 Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: JOURNAL OF CUTANEOUS PATHOLOGY; v. 46, n. 10, p. 778-783, OCT 2019.
Citações Web of Science: 0
Resumo

The low-fat and fat-free spindle cell lipomas (SCLs) are rare and often mistaken for other benign and malignant morphological mimics, because of the fact that the diagnosis relies on its non-lipogenic component analysis. Here, we report the clinicopathological features of two oral SCLs (low-fat and fat-free variants). Both lesions presented clinically as an asymptomatic nodule, which initially yielded diagnostic difficulties on the morphological analysis alone. One case was diagnosed as low-fat SCL on the lower lip in a 29-year-old man, and the other as fat-free SCL on the buccal mucosa in a 46-year-old man. In both cases, immunohistochemistry showed strong positivity for CD34 and, remarkably, retinoblastoma (Rb) protein was deficient. Mast cell (MC) tryptase and toluidine blue stain highlighted numerous MCs distributed throughout all tumor stroma. Alpha-SMA and desmin were negative. S100 evidenced scarce adipocytes only in the low-fat SCL case. Conservative surgical treatment was performed and no recurrence was noticed in about 2-year of follow-up in both cases. Because of the potential pitfalls, careful morphological analysis of the tumor stroma in the low-fat/fat-free SCL diagnosis, supported by immunohistochemistry (especially CD34, Rb and MC tryptase), is strongly recommended. To the best of our knowledge, these are the first and second cases reported of fat-free and low-fat SCL in the oral cavity. (AU)

Processo FAPESP: 18/12734-2 - Caracterização imunoistoquímica comparativa de subgrupos de células dendríticas e oncogênese viral no carcinoma espinocelular oral e orofaríngeo
Beneficiário:Heitor Albergoni da Silveira
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
Beneficiário:Jorge Esquiche León
Modalidade de apoio: Auxílio à Pesquisa - Regular