In situ immune response in human dermatophytosis: possible role of Langerhans cells (CD1a+) as a risk factor for dermatophyte infection

Autor(es)

Ana Paula Carvalho Reis ; Franciele Fernandes Correia ; Thais Martins Jesus ; Carla Pagliari ^[4] ; Neusa Y Sakai-Valente ^[5] ; Walter Belda Júnior ^[6] ; Paulo Ricardo Criado ^[7] ; Gil Benard ; Maria Gloria Teixeira Sousa

• Tipo de documento: Artigo Científico
• Fonte: Revista do Instituto de Medicina Tropical de São Paulo; v. 61, 2019-10-10.

Resumo

ABSTRACT Dermatophytosis is a cutaneous mycosis caused by a plethora of keratinophilic fungi, but Trichophyton rubrum is the most common etiological agent. Despite its high prevalence worldwide, little is known about the host defense mechanisms in this infection, particularly the in situ immune response. Using an immunohistochemistry approach, we investigated the density of CD1a+, factor XIIIa+ and CD68+ cells in the skin of dermatophytosis patients. Langerhans cells (CD1a+ cells) were significantly decreased in the epidermis of patients, both in affected and unaffected areas. In the dermis, however, no differences in the density of macrophages (CD68+ cells) and dermal dendrocytes (factor XIIIa+ cells) were observed. These results suggest that the decreased number of Langerhans cells may be a risk factor for development of dermatophytosis. (AU)

• Processo FAPESP: 17/26208-8 - Dermatofitose crônica disseminada por Trichophyton rubrum: papel dos neutrófilos nos mecanismos efetores e na modulação da resposta adaptativa na infecção humana
• Beneficiário: Maria da Gloria Sousa Stafocker
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 16/16369-1 - Dermatofitose crônica disseminada por Trichophyton rubrum: papel dos neutrófilos nos mecanismos efetores e na modulação da resposta adaptativa na infecção humana
• Beneficiário: Maria da Gloria Sousa Stafocker
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/24175-8 - Resposta imune in situ na dermatofitose crônica disseminada humana: participação dos receptores de lectina do tipo c
• Beneficiário: Ana Paula Carvalho dos Reis
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica