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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In situ immune response in human dermatophytosis: possible role of Langerhans cells (CD1a+) as a risk factor for dermatophyte infection

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Author(s):
Ana Paula Carvalho Reis ; Franciele Fernandes Correia ; Thais Martins Jesus ; Carla Pagliari [4] ; Neusa Y Sakai-Valente [5] ; Walter Belda Júnior [6] ; Paulo Ricardo Criado [7] ; Gil Benard ; Maria Gloria Teixeira Sousa
Total Authors: 9
Document type: Journal article
Source: Revista do Instituto de Medicina Tropical de São Paulo; v. 61, 2019-10-10.
Abstract

ABSTRACT Dermatophytosis is a cutaneous mycosis caused by a plethora of keratinophilic fungi, but Trichophyton rubrum is the most common etiological agent. Despite its high prevalence worldwide, little is known about the host defense mechanisms in this infection, particularly the in situ immune response. Using an immunohistochemistry approach, we investigated the density of CD1a+, factor XIIIa+ and CD68+ cells in the skin of dermatophytosis patients. Langerhans cells (CD1a+ cells) were significantly decreased in the epidermis of patients, both in affected and unaffected areas. In the dermis, however, no differences in the density of macrophages (CD68+ cells) and dermal dendrocytes (factor XIIIa+ cells) were observed. These results suggest that the decreased number of Langerhans cells may be a risk factor for development of dermatophytosis. (AU)

FAPESP's process: 17/26208-8 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection
Grantee:Maria da Gloria Sousa Stafocker
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 16/16369-1 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection
Grantee:Maria da Gloria Sousa Stafocker
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 18/24175-8 - In situ immune response in human disseminated chronic dermatophytosis: participation of c type lectin receptors
Grantee:Ana Paula Carvalho dos Reis
Support Opportunities: Scholarships in Brazil - Scientific Initiation