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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A New Electrochemical Platform Based on a Polyurethane Composite Electrode Modified with Magnetic Nanoparticles Coated with Molecularly Imprinted Polymer for the Determination of Estradiol Valerate in Different Matrices

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Autor(es):
Bergamin, Bruna [1, 2] ; Pupin, Rafael R. [1, 2] ; Wong, Ademar [1, 2] ; Sotomayor, Maria D. P. T. [1, 2]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Inst Quim, Dept Quim Analit, BR-14801970 Araraquara, SP - Brazil
[2] Inst Nacl Tecnol Alternat Deteccao Avaliacao Toxi, BR-14801970 Araraquara, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Journal of the Brazilian Chemical Society; v. 30, n. 11, SI, p. 2344-2354, NOV 2019.
Citações Web of Science: 0
Resumo

A polyurethane composite electrode modified with magnetic nanoparticles (mag; Fe3O4) coated with molecularly imprinted polymers (MIPs) was developed for the electrochemical determination of estradiol valerate. Chemical and morphological analyses of the mag-MIP were performed using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS), with the aim of characterizing this new material. The efficiency of adsorption of estradiol valerate by the mag-MIP was tested in binding experiments using an electrochemical method. For this, different electrodes (mag-MIP / graphite-epoxy composite (GEC), mag-non-imprinted polymer (NIP) / GEC, mag / GEC, and GEC) were evaluated by square-wave voltammetry (SWV). After 10 min at open circuit potential, increases in the current signal of 1.9, 2.1, and 3.0 times were obtained, comparing the electrochemical response of the mag-MIP / GEC sensor to the mag-NIP / GEC, mag / GEC, and GEC sensors, respectively. Under optimized conditions, the mag-MIP / GEC showed a linear concentration range for estradiol valerate of 5.0 x 10(-7) to 7.5 x 10(-4) mol L-1 and a limit of detection of 1.0 x 10(-8) mol L-1. The proposed sensor was applied in the analysis of pharmaceutical, human urine, and river water samples. The recovery values determined using high performance liquid chromatography (HPLC)-UV and the electrochemical method were in agreement and were near 100%, demonstrating the reliability of the proposed method. (AU)

Processo FAPESP: 14/50945-4 - INCT 2014: Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos
Beneficiário:Maria Valnice Boldrin
Linha de fomento: Auxílio à Pesquisa - Temático