HLA-G Polymorphisms Are Associated with Non-Segmental Vitiligo among Brazilians

Autor(es):Mostrar menos -

Veiga-Castelli, Luciana ^[1] ; de Oliveira, Maria Luiza ^[1] ; Pereira, Alison ^[1] ; Debortoli, Guilherme ^[1] ; Marcorin, Leticia ^[1] ; Fracasso, Nadia ^[1] ; Silva, Guilherme ^[2] ; Souza, Andreia ^[3] ; Massaro, Juliana ^[4] ; Simoes, Aguinaldo Luiz ^[1] ; Sabbagh, Audrey ^[5] ; Cardili, Renata ^[4] ; Donadi, Eduardo ^[4] ; Castelli, Erick ^[3] ; Mendes-Junior, Celso ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Pesquisas Forenses & Genom, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Sch Med, Expt Res Unit UNIPEX, Mol Genet & Bioinformat Lab, BR-18618687 Botucatu, SP - Brazil

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-14049900 Ribeirao Preto - Brazil

^[5] Univ Paris 05, Sorbonne Paris Cite, Fac Pharm Paris, UMR MERIT IRD 216, F-75006 Paris - France

• Tipo de documento: Artigo Científico
• Fonte: BIOMOLECULES; v. 9, n. 9 SEP 2019.
• Citações Web of Science: 0

Resumo

(1) Background: Vitiligo is characterized by white patches on the skin caused by loss of melanocyte activity or the absence of these cells. The available treatments minimize the symptoms by retarding the process of skin depigmentation or re-pigmenting the affected regions. New studies are required for a better comprehension of the mechanisms that trigger the disease and for the development of more efficient treatments. Studies have suggested an autoimmune feature for vitiligo, based on the occurrence of other autoimmune diseases in vitiligo patients and their relatives, and on the involvement of genes related to the immune response. (2) Methods: We evaluated, by massive parallel sequencing, polymorphisms of the HLA-G gene in vitiligo patients and control samples, to verify if variants of this gene could influence the susceptibility to vitiligo. (3) Results: We detected an association with non-segmental vitiligo regarding the haplotype Distal-010101a/G{*}01:01:01:01/UTR-1, adjusting for population stratification by using ancestry-informative markers (AIMs). (4) Conclusions: It remains unclear whether the HLA-G variants associated with vitiligo were detected because of the high linkage disequilibrium (LD) with HLA-A{*}02, or if the HLA-A variants previously reported as associated with vitiligo were detected because of the high LD with HLA-G{*}01:01:01:01/UTR-1, or if both genes jointly contribute to vitiligo susceptibility. (AU)

• Processo FAPESP: 13/15447-0 - Sequenciamento de nova geração das regiões regulatórias e exônicas de dez genes envolvidos na biossíntese de melanina em amostra da população brasileira
• Beneficiário: Celso Teixeira Mendes Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular