Cross talk between mineral metabolism and meat quality: a systems biology overview

Autor(es)

Diniz, Wellison J. da Silva ^[1] ; Banerjee, Priyanka ^[2] ; Regitano, Luciana C. A. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Ctr Biol & Hlth Sci CCBS, Sao Carlos, SP - Brazil

^[2] Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby - Denmark

^[3] Empresa Brasileira Pesquisa Agr, Embrapa Pecuaria Sudeste, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Physiological Genomics; v. 51, n. 11, p. 529-538, NOV 2019.
• Citações Web of Science: 0

Resumo

Meat quality has an inherent complexity because of the multiple interrelated causative factors and layers of feedback regulation. Understanding the key factors and their interactions has been challenging, despite the availability of remarkable high-throughput tools and techniques that have provided insights on muscle metabolism and the genetic basis of meat quality. Likewise, we have deepened our knowledge about mineral metabolism and its role in cell functioning. Regardless of these facts, complex traits like mineral content and meat quality have been studied under reductionist approaches. However, as these phenotypes arise from complex interactions among different biological layers (genome, transcriptome, proteome, epigenome, etc.), along with environmental effects, a holistic view and systemic-level understanding of the genetic basis of complex phenotypes are in demand. Based on the state of the art, we addressed some of the questions regarding the interdependence of meat quality traits and mineral content. Furthermore, we sought to highlight potential regulatory mechanisms arising from the genes, miRNAs, and mineral interactions, as well as the pathways modulated by this interplay affecting muscle, mineral metabolism, and meat quality. By answering these questions, we did not intend to give an exhaustive review but to identify the key biological points, the challenges, and benefits of integrative genomic approaches. (AU)

• Processo FAPESP: 15/09158-1 - Identificação de redes gênicas de coexpressão e dos mecanismos regulatórios associados à composição mineral e qualidade de carne em bovinos
• Beneficiário: Wellison Jarles da Silva Diniz
• Modalidade de apoio: Bolsas no Brasil - Doutorado