A mini-review on drug delivery through wafer technology: Formulation and manufacturing of buccal and oral lyophilizates

Autor(es)

Ribeiro Costa, Juliana Souza ^{[1, 2]} ; Cruvinel, Karen de Oliveira ^[1] ; Oliveira-Nascimento, Laura ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Pharmaceut Sci, Rua Candido Portinari 200, BR-13083871 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Rua Monteiro Lobato 255, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF ADVANCED RESEARCH; v. 20, p. 33-41, NOV 2019.
• Citações Web of Science: 1

Resumo

A great number of patients have difficulty swallowing or needle fear. Therefore, buccal and orodispersible dosage forms (ODFs) represent an important strategy to enhance patient compliance. Besides not requiring water intake, swallowing or needles, these dosage forms allow drug release modulation. ODFs include oral lyophilizates or wafers, which present even faster disintegration than its compressed counterparts. Lyophilization can also produce buccal wafers that adhere to mucosa for sustained drug release. Due to the subject relevance and recent research growth, this review focused on oral lyophilizate production technology, formulation features, and therapy gains. It includes Critical Quality Attributes (CQA) and Critical Process Parameters (CPP) and discusses commercial and experimental examples. In sum, the available commercial products promote immediate drug release mainly based on biopolymeric matrixes and two production technologies. Therapy gains include substitution of traditional treatments depending on parenteral administration and patient preference over classical therapies. Experimental wafers show promising advantages as controlled release and drug enhanced stability. All compiled findings encourage the development of new wafers for several diseases and drug molecules. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of Cairo University. (AU)

• Processo FAPESP: 17/06613-5 - Desenvolvimento de wafers biopoliméricos para administração bucal de anestésicos locais
• Beneficiário: Karen de Oliveira Cruvinel
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/14457-5 - Carreadores baseados em lipídios (SLN/NLC e lipossomas com gradiente iônico) como estratégia para aumentar a encapsulação e a potência de anestésicos locais
• Beneficiário: Eneida de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Temático