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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Interaction of naringin and naringenin with DPPC monolayer at the air-water interface

Texto completo
Autor(es):
Souza, F. R. [1] ; Fornasier, F. [1] ; Souza, L. M. P. [1] ; Penafiel, M. P. [1] ; Nascimento, J. B. [1] ; Malfatti-Gasperini, A. A. [2] ; Pimentel, A. S. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Pontificia Univ Catolica Rio de Janeiro, Dept Quim, BR-22453900 Rio De Janeiro, RJ - Brazil
[2] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Synchrotron Light Lab LNLS, BR-13083970 Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 584, JAN 2 2020.
Citações Web of Science: 2
Resumo

The interaction of naringin and naringenin with DPPC monolayer at the air-water interface was investigated by coarse grained molecular dynamics and grazing incidence X-ray off-specular scattering (GIXOS). By molecular dynamics, we found that the DPPC monolayer is not disturbed by the addition of flavonoids at the surface tension of 28 mN m(-1). The flavonoids are located in the region of phospholipid polar heads. The GIXOS experiments show that the addition of flavonoids does not change the film thickness at the surface tension of 28 mN m-1, which is in excellent agreement with molecular dynamics simulation. Our very preliminary study indicates that DPPC may be used as a delivery system for the administration of naringenin and naringin to the lung. (AU)

Processo FAPESP: 14/50983-3 - INCT 2014: fluidos complexos
Beneficiário:Antonio Martins Figueiredo Neto
Modalidade de apoio: Auxílio à Pesquisa - Temático