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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interaction of naringin and naringenin with DPPC monolayer at the air-water interface

Full text
Author(s):
Souza, F. R. [1] ; Fornasier, F. [1] ; Souza, L. M. P. [1] ; Penafiel, M. P. [1] ; Nascimento, J. B. [1] ; Malfatti-Gasperini, A. A. [2] ; Pimentel, A. S. [1]
Total Authors: 7
Affiliation:
[1] Pontificia Univ Catolica Rio de Janeiro, Dept Quim, BR-22453900 Rio De Janeiro, RJ - Brazil
[2] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Synchrotron Light Lab LNLS, BR-13083970 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 584, JAN 2 2020.
Web of Science Citations: 2
Abstract

The interaction of naringin and naringenin with DPPC monolayer at the air-water interface was investigated by coarse grained molecular dynamics and grazing incidence X-ray off-specular scattering (GIXOS). By molecular dynamics, we found that the DPPC monolayer is not disturbed by the addition of flavonoids at the surface tension of 28 mN m(-1). The flavonoids are located in the region of phospholipid polar heads. The GIXOS experiments show that the addition of flavonoids does not change the film thickness at the surface tension of 28 mN m-1, which is in excellent agreement with molecular dynamics simulation. Our very preliminary study indicates that DPPC may be used as a delivery system for the administration of naringenin and naringin to the lung. (AU)

FAPESP's process: 14/50983-3 - INCT 2014: complex fluids
Grantee:Antonio Martins Figueiredo Neto
Support Opportunities: Research Projects - Thematic Grants