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Study of the interaction of the glycopeptide vancomycin with cell membrane models formed by lipid Langmuir films

Grant number: 19/04402-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2019
Effective date (End): January 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Luciano Caseli
Grantee:Heung Jin Alves Santana
Home Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

In this project, we intend to study the action of vancomycin with Langmuir films of phospholipids, which serve as simple models of cell membranes. The phospholipids to be used will be dipalmitoyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidyl ethanolamine (DPPE), co-mixed with the bioactive. The interaction of vancomycin with the phospholipid monolayers will be evaluated by means of pressure and surface potential measurements, Brewster angle microscopy, infrared spectroscopy, and surface rheology. The results will be evaluated from the perspective of possible biological implications, inferred from the effects caused by the bioactive on the artificial membranes.