|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||July 01, 2019|
|Effective date (End):||January 31, 2020|
|Field of knowledge:||Physical Sciences and Mathematics - Chemistry - Physical-Chemistry|
|Principal researcher:||Luciano Caseli|
|Grantee:||Heung Jin Alves Santana|
|Home Institution:||Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil|
In this project, we intend to study the action of vancomycin with Langmuir films of phospholipids, which serve as simple models of cell membranes. The phospholipids to be used will be dipalmitoyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidyl ethanolamine (DPPE), co-mixed with the bioactive. The interaction of vancomycin with the phospholipid monolayers will be evaluated by means of pressure and surface potential measurements, Brewster angle microscopy, infrared spectroscopy, and surface rheology. The results will be evaluated from the perspective of possible biological implications, inferred from the effects caused by the bioactive on the artificial membranes.