In this project, we intend to study the action of vancomycin with Langmuir films of phospholipids, which serve as simple models of cell membranes. The phospholipids to be used will be dipalmitoyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidyl ethanolamine (DPPE), co-mixed with the bioactive. The interaction of vancomycin with the phospholipid monolayers will be evaluated by means of pressure and surface potential measurements, Brewster angle microscopy, infrared spectroscopy, and surface rheology. The results will be evaluated from the perspective of possible biological implications, inferred from the effects caused by the bioactive on the artificial membranes.
News published in Agência FAPESP Newsletter about the scholarship: