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Smart surfaces: nanostructured and bioinspired systems for the investigation of molecular interactions in membrane models and for the production of devices for biosensors and environmental analysis


In this project, we intended to incorporate bioactive materials, synthetic or natural, on nanostructured bioinspired surfaces, including Langmuir monolayers, Langmuir-Blodgett films and layer-by-layer films. Some candidates are those with high pharmacological interest, associated with events that occur in cell membranes, either by simply destroying the cell membrane as for antimicrobial and antifungal activities, or by acting on cellular mechanisms associated with biochemical events such as signaling and cellular transport, characterizing their expression in microbes and tumor cells. Also, we intended to immobilize enzymes, antibodies and pieces of nucleic acids in nanostructured films to investigate the properties of these substances in terms of molecular recognition, and the possibility of incorporating them in a bioinspired system. For that, substances that assist in the molecular accommodation increasing the biological activity can be studied. Some candidates are polysaccharides and carbon nanotubes. In this sense, we emphasize the strong interaction that the applicant already has with groups within the institution, specialists in obtaining bioactive materials, and experts in molecular biology. This project therefore aims at studying smart surfaces constructed from bioinspired interfaces organized at the molecular level. (AU)

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Scientific publications (22)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, JOAO VICTOR N.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. Thymol in cellular membrane models formed by negative charged lipids causes aggregation at the air-water interface. Chemical Physics Letters, v. 717, p. 87-90, . (15/23446-0, 13/14262-7)
FERREIRA, JOAO VICTOR N.; CAPELLO, TABATA M.; SIQUEIRA, LEONARDO J. A.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. Mechanism of Action of Thymol on Cell Membranes Investigated through Lipid Langmuir Monolayers at the Air-Water Interface and Molecular Simulation. Langmuir, v. 32, n. 13, p. 3234-3241, . (15/23446-0, 13/10213-1)
AYOUB, FABIO DE PAULA; CASELI, LUCIANO. Controlling the molecular architecture of lactase immobilized in Langmuir-Blodgett films of phospholipids to modulate the enzyme activity. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 150, p. 8-14, . (15/23446-0, 14/12557-2)
RODRIGUES, JEFFERSON CARNEVALLE; CASELI, LUCIANO. Incorporation of bacitracin in Langmuir films of phospholipids at the air-water interface. Thin Solid Films, v. 622, p. 95-103, . (15/23446-0)
TELES ROSSINI, CABO VINICIUS; MOLINA, CELSO; CASELI, LUCIANO. Langmuir and Langmuir-Blodgett films of di-ureasil hybrid compounds containing phosphotungstic acid. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 524, p. 35-42, . (15/23446-0, 14/12557-2, 13/14262-7)
DE SOUZA, KARINE DAMACENO; PEREZ, KATIA REGINA; DURAN, NELSON; JUSTO, GISELLE ZENKER; CASELI, LUCIANO. Interaction of violacein in models for cellular membranes: Regulation of the interaction by the lipid composition at the air-water interface. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 160, p. 247-253, . (15/23446-0)
GONCALVES, GIULIA ELISA G.; MORAIS, THIAGO R.; LAGO, JOAO HENRIQUE G.; CASELI, LUCIANO. Incorporation of polygodial in Langmuir films of selected lipids. Thin Solid Films, v. 669, p. 19-28, . (15/23446-0, 18/07885-1)
TELES ROSSINI, CAIO VINICIUS; MOLINA, CELSO; CASELI, LUCIANO. Immobilization of urease in Langmuir-Blodgett films of di-ureasil hybrid compounds. Thin Solid Films, v. 670, p. 17-23, . (15/23446-0, 14/12557-2, 13/14262-7)
RODRIGUES, JEFFERSON CARNEVALLE; CASELI, LUCIANO. Lipids mediating the interaction of metronidazole with cell membrane models at the air-water interface. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 171, p. 377-382, . (15/23446-0, 13/14262-7)
BARBOSA, CAMILA GOUVEIA; LA-SCALEA, MAURO AQUILES; CASELI, LUCIANO; PERES, LAURA OLIVEIRA. Copolymers and enzymes blended as LB films changing the bioelectronics properties of interfaces. COLLOID AND INTERFACE SCIENCE COMMUNICATIONS, v. 27, p. 40-44, . (14/50869-6, 15/23446-0)
JAROQUE, GUILHERME NUNEZ; SARTORELLI, PATRICIA; CASELI, LUCIANO. Interfacial vibrational spectroscopy and Brewster angle microscopy distinguishing the interaction of terpineol in cell membrane models at the air-water interface. Biophysical Chemistry, v. 246, p. 1-7, . (15/23446-0, 13/14262-7)
SAKAI, ANDREI; DE SOUSA MESQUITA, ANA PAULA; DE CASTRO LEVATTI, ERICA VALADARES; STRAUS, ANITA HILDA; NADER, HELENA B.; LOPES, CARLA CRISTINA; CASELI, LUCIANO. Interaction of Trastuzumab with biomembrane models at air-water interfaces mimicking cancer cell surfaces. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1861, n. 10, . (19/03239-0, 15/23446-0, 13/14262-7)
SORIANO, GUSTAVO BONOMI; OLIVEIRA, ROSELAINE DA SILVA; CAMILO, FERNANDA FERRAZ; CASELI, LUCIANO. Interaction of non-aqueous dispersions of silver nanoparticles with cellular membrane models. Journal of Colloid and Interface Science, v. 496, p. 111-117, . (14/23065-3, 15/23446-0)
DA ROCHA JUNIOR, CARLOS; CASELI, LUCIANO. Adsorption and enzyme activity of asparaginase at lipid Langmuir and Langmuir-Blodgett films. Materials Science & Engineering C-Materials for Biological Applications, v. 73, p. 579-584, . (15/23446-0, 15/10446-1, 14/12557-2)
BARBOSA, CAMILA GOUVEIA; CASELI, LUCIANO; PERES, LAURA OLIVEIRA. Conjugated polymers nanostructured as smart interfaces for controlling the catalytic properties of enzymes. Journal of Colloid and Interface Science, v. 476, p. 206-213, . (15/23446-0)
GOTO, THIAGO E.; LOPES, CARLA C.; NADER, HELENA B.; SILVA, ANIELLE C. A.; DANTAS, NOELI O.; SIQUEIRA, JR., JOSE R.; CASELI, LUCIANO. CdSe magic-sized quantum dots incorporated in biomembrane models at the air-water interface composed of components of tumorigenic and non-tumorigenic cells. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1858, n. 7, A, p. 1533-1540, . (15/23446-0)
ROCHA, JEFFERSON M.; PAVINATTO, ADRIANA; NOBRE, THATYANE M.; CASELI, LUCIANO. Acylated Carrageenan Changes the Physicochemical Properties of Mixed Enzyme-Lipid Ultrathin Films and Enhances the Catalytic Properties of Sucrose Phosphorylase Nanostructured as Smart Surfaces. Journal of Physical Chemistry B, v. 120, n. 24, p. 5359-5366, . (15/23446-0)
RODRIGUES, RAUL T.; MORAIS, PAULO V.; NORDI, CRISTINA S. F.; SCHOENING, MICHAEL J.; SIQUEIRA, JR., JOSE R.; CASELI, LUCIANO. Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films. Langmuir, v. 34, n. 9, p. 3082-3093, . (15/23446-0, 16/01867-6)
GROSSO SALIS, LUIZ FERNANDO; JAROQUE, GUILHERME NUNEZ; BERRIO ESCOBAR, JHON FERNANDO; GIORDANI, CRISTIANO; MARTINEZ MARTINEZ, ALEJANDRO; MARQUEZ FERNANDEZ, DIANA MARGARITA; CASTELLI, FRANCESCO; SARPIETRO, MARIA GRAZIA; CASELI, LUCIANO. Interaction of 3 `,4 `,6 `-trimyristoyl-uridine derivative as potential anticancer drug with phospholipids of tumorigenic and non-tumorigenic cells. Applied Surface Science, v. 426, p. 77-86, . (15/23446-0)
GUIMARAES GONCALVES, GIULIA ELISA; MORAIS, THIAGO RAHAL; GOMES, KAIO DE SOUZA; COSTA-SILVA, THAIS ALVES; TEMPONE, ANDRE GUSTAVO; GHILARDI LAGO, JOAO HENRIQUE; CASELI, LUCIANO. Antitrypanosomal activity of epi-polygodial from Drimys brasiliensis and its effects in cellular membrane models at the air-water interface. BIOORGANIC CHEMISTRY, v. 84, p. 186-191, . (15/23446-0, 13/14262-7, 18/07885-1, 15/23403-9)

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