Intensive investigation of synthetic cationic vesicles properties of alkyl dimethylammonium, DnDAB, n = 10-18 is of represent a great importance for basic and applied science, because it is a model for biological membrane, and especially for drug delivery and cell transfection in genetherapy. In this project we propose a systematic study of physicochemical properties related with DnDAB vesicles formation and interaction with water soluble polymers (polyethylene glycol or polyacrilic acid, for example polymers. It will be varied the concentration of DnDAB and the relative amount of additive in order to obtain the properties of the vesicles and the vesicle-additive complexes, such as the hydrodynamic radius, the gel-liquid crystalline, pre and post-transitions states temperature, and the surface potentials (zeta potentials). The dynamic interactions between vesicles and polymers will be monitored trough Langmuir-Blodgett techniques, which is largely employed in biological context due high sensibility detection in interfacial systems that simulate cell membrane interacting with different species. The monolayer transfer will be performed by adequate immobilized groups at the substrate; the physicochemical properties related with organized systems will be investigated. The interdisciplinarity of this project recognizes the relevance of academic studies to applications in different research areas.
News published in Agência FAPESP Newsletter about the scholarship: