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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The assembly of dialkyldimethylammonium bromide cationic lipids as vesicles or monolayers in presence of poly(ethylene glycol)

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Adati, Renata D. [1] ; Feitosa, Eloi [1]
Total Authors: 2
[1] Sao Paulo State Univ, Dept Phys, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Thermochimica Acta; v. 613, p. 71-76, AUG 10 2015.
Web of Science Citations: 1

The interaction between polymer and lipid vesicles may result in stabilization and formation of highly ordered networks, which can mimic biological membranes and be used as drug delivery system. Here we used differential scanning calorimetry (DSC) and Langmuir-Blodgett (LB) techniques to describe the effect of the nonionic water-soluble poly(ethylene glycol), PEG 35 kDa, on vesicles or monolayers from the cationic dialkyldimethylammonium bromide, D(n)DAB (n = 12-18). Based on DSC data, up to 10 Wt%, PEG plays minor role on the thermal behavior of D(n)DAB, thus preserving the bilayer structure. Above 10 wt% PEG, there is no bilayer for n = 12-16, while for n = 18 there remains bilayer structures even in presence of 30 wt% PEG. The effect of PEG on the Langmuir monolayer of D(18)DAB depends on the amount of PEG in the sub-phase. In presence of up to ca 1 wt%, PEG yields more compressible films, while at higher polymer concentration the film is more extended and the collapse pressure is lower, most probably due to lipid solubility by the polymer solution. The PEG-D,DAB complexes have potential application in controlled drug release by microgel nanoparticles. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/03566-0 - Studies on self-organized systems of dialkyldimethylammonium bromide in aqueous solution and at liquid and solid interfaces
Grantee:Eloi da Silva Feitosa
Support Opportunities: Regular Research Grants
FAPESP's process: 11/07414-0 - Study of cationic lipid and water soluble polymers polymers interaction in solution and in vesicular molecular films as biomimetic model systems
Grantee:Renata Danielle Adati
Support Opportunities: Scholarships in Brazil - Post-Doctoral