Effect of metallization on porphyrin photoacoustic response

Autor(es)

Amado, Andre Miele ^[1] ; Uliana, Joao Henrique ^[1] ; Pavan, Theo Zeferino ^[1] ; Borissevitch, Iouri ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Phys Dept, Ribeirao Preto, SP - Brazil

^[2] Univ Fed Goias, Inst Phys, Goiania, Go - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Chemical Physics Letters; v. 738, JAN 2020.
• Citações Web of Science: 1

Resumo

Photoacoustic imaging (PAI) has been evaluated to visualize small neoplastic lesions inside normal tissues. PAI is based on the detection of pressure waves generated due to the absorption of light energy by a photosensitizer (PS) within the tissue. Porphyrins possess high affinity to tumor tissue thus can be considered as an appropriate PS. PS complexation with metals can increase the heat production at the PS excitation; therefore, increasing the PA response. We have demonstrated the increase of the TPPS4 and TMPyP porphyrin PA response at their complexation with Fe3+, Mn3+, Cu2+ and Zn2+ metal ions in aqueous solutions. (AU)

• Processo FAPESP: 16/22374-8 - Análise da oxigenação sanguínea em tumores por meio de imagens fotoacústicas.
• Beneficiário: João Henrique Uliana
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/18854-6 - Imagens fotoacústicas e ultrassônicas para caracterização de tecidos viscoelásticos
• Beneficiário: Theo Zeferino Pavan
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores