Effect of metallization on porphyrin photoacoustic response

Author(s)

Amado, Andre Miele ^[1] ; Uliana, Joao Henrique ^[1] ; Pavan, Theo Zeferino ^[1] ; Borissevitch, Iouri ^{[2, 1]}

Affiliation

^[1] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Phys Dept, Ribeirao Preto, SP - Brazil

^[2] Univ Fed Goias, Inst Phys, Goiania, Go - Brazil

• Document type: Journal article
• Source: Chemical Physics Letters; v. 738, JAN 2020.
• Web of Science Citations: 1

Abstract

Photoacoustic imaging (PAI) has been evaluated to visualize small neoplastic lesions inside normal tissues. PAI is based on the detection of pressure waves generated due to the absorption of light energy by a photosensitizer (PS) within the tissue. Porphyrins possess high affinity to tumor tissue thus can be considered as an appropriate PS. PS complexation with metals can increase the heat production at the PS excitation; therefore, increasing the PA response. We have demonstrated the increase of the TPPS4 and TMPyP porphyrin PA response at their complexation with Fe3+, Mn3+, Cu2+ and Zn2+ metal ions in aqueous solutions. (AU)

• FAPESP's process: 16/22374-8 - Blood oxygenation analysis in tumors using photoacoustic imaging
• Grantee: João Henrique Uliana
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/18854-6 - Photoacoustic and ultrasound imaging applied to tissue characterization
• Grantee: Theo Zeferino Pavan
• Support Opportunities: Research Grants - Young Investigators Grants