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Blood oxygenation analysis in tumors using photoacoustic imaging

Grant number: 16/22374-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2017
Effective date (End): March 31, 2021
Field of knowledge:Engineering - Biomedical Engineering - Medical Engineering
Principal researcher:Theo Zeferino Pavan
Grantee:João Henrique Uliana
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/18854-6 - Photoacoustic and ultrasound imaging applied to tissue characterization, AP.JP

Abstract

Photoacoustic imaging consists in light absorption by a sample generating acoustic waves due to photoacoustic effect. If temporal stress confinement is satisfied a broadband pressure wave will be generated and photoacoustic images can be acquired using a clinical ultrasound machine. Photoacoustic imaging combines contrast of optical images and spatial resolution of ultrasonic images. Due to the capacity of encoding optical proprieties distribution in acoustic waves, this image technique can be used to imaging blood vessels to diagnostics and monitoring of pathologies that change vasculature. Hemoglobin is an endogen chromophore that highly absorbs light, allowing photoacoustic imaging of vasculature. The specific optical absorption of hemoglobin is influenced by oxygenation and present absorption peak in 850 nm for oxy-hemoglobin and 750 nm for deoxy-hemoglobin. Thus, photoacoustic images generated using a LASER with different wave lengths can use this contrast mechanism to investigate oxygen heterogeneity in tumors. Other studies have shown increase in oxygenation in tumor after mild hyperthermia (heating the tissue to around 40°C) due to enhancement in perfusion and decrease of oxygen consumption. Mild hyperthermia in tumoral region can reduce the amount of hypoxic cells, increasing radiosensitivity and improving radiotherapy eficience. Therefore, it is proposed photoacoustic images to evaluate tumor oxygenation in an animal murine model. This evaluation will also be performed in tumors exposed to mild hyperthermia using high intensity focal ultrasound.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ULIANA, JOAO H.; SAMPAIO, DIEGO R. T.; FERNANDES, GUILHERME S. P.; BRASSESCO, MARIA S.; NOGUEIRA-BARBOSA, MARCELLO H.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer. SENSORS, v. 20, n. 14, . (17/14482-8, 16/22374-8, 13/18854-6, 15/05684-0)
AMADO, ANDRE MIELE; ULIANA, JOAO HENRIQUE; PAVAN, THEO ZEFERINO; BORISSEVITCH, IOURI. Effect of metallization on porphyrin photoacoustic response. Chemical Physics Letters, v. 738, . (16/22374-8, 13/18854-6)
CABRELLI, LUCIANA C.; ULIANA, JOAO H.; DA CRUZ JUNIOR, LUISMAR B.; BACHMANN, LUCIANO; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. Glycerol-in-SEBS gel as a material to manufacture stable wall-less vascular phantom for ultrasound and photoacoustic imaging. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, v. 7, n. 6, . (13/18854-6, 16/22374-8)
HADADIAN, YASER; ULIANA, JOAO H.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. A Novel Theranostic Platform: Integration of Magnetomotive and Thermal Ultrasound Imaging With Magnetic Hyperthermia. IEEE Transactions on Biomedical Engineering, v. 68, n. 1, p. 68-77, . (16/22374-8, 13/18854-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ULIANA, João Henrique. Systems of image and photoacoustic spectroscopy. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.