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Photoacoustic monitoring of tissue temperature during hyperthermia treatment

Grant number: 14/26598-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2015
Effective date (End): September 30, 2016
Field of knowledge:Engineering - Biomedical Engineering - Medical Engineering
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Theo Zeferino Pavan
Grantee:João Henrique Uliana
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/18854-6 - Photoacoustic and ultrasound imaging applied to tissue characterization, AP.JP


Magnetic hyperthermia is a noninvasive cancer treatment technique, based on magnetic nanoparticles exposed to an external alternating magnetic field. These particles act as heat sources for target thermal therapy, which is an alternative to surgery, and can be used when tumors are close to vital organs. The principle of magnetic hyperthermia involves the application of external alternating magnetic fields interacting with magnetic nanoparticles concentrated in the tumor region. During interaction, part of the energy is dissipated as heat, which causes local increase of temperature, destroying the tumoral tissue without damaging healthy tissue. However, to improve effectiveness in the results, it is necessary to know the magnitude of the temperature increase and also the spatial distribution of magnetic particles for the focus on tumor tissue. The aim of our study is to monitor the temperature and spatial distribution of magnetic particles using photoacoustic images. The photoacoustic signal generated from the interaction of short laser pulses with the tissue is dependent on the mechanical and thermal properties of the tissue, as its optical absorption profile, which is used for mapping temperature and spatial distribution of the particles magnetic. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JOÃO HENRIQUE ULIANA; DIEGO RONALDO THOMAZ SAMPAIO; ANTONIO ADILTON OLIVEIRA CARNEIRO; THEO ZEFERINO PAVAN. Photoacoustic-based thermal image formation and optimization using an evolutionary genetic algorithm. Res. Biomed. Eng., v. 34, n. 2, p. 147-156, . (13/18854-6, 14/26598-2, 15/05684-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ULIANA, João Henrique. Tecidual temperature monitoring using photoacoustic images during hyperthermia treatments.. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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