Photoacoustic and ultrasound imaging applied to tissue characterization

• Grant number: 13/18854-6
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: July 01, 2014
• End date: June 30, 2019
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Theo Zeferino Pavan
• Grantee: Theo Zeferino Pavan
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Antonio Adilton Oliveira Carneiro ; Iouri Borissevitch ; Marcello Henrique Nogueira Barbosa
• Associated research grant(s): 21/06728-2 - Photoacoustic and ultrasound imaging for theranostic purposes, AP.JP2; 19/13450-0 - 2019 IEEE International Ultrasonics Symposium, AR.EXT; 14/26889-7 - Visits, conferences and scientific collaborations with the innovation group in medical instrumentation and ultrasound of USP in Ribeirão Preto, AV.EXT
• Associated scholarship(s): 17/14482-8 - Artifacts reduction on dual mode ultrasound/photoacoustic images, BP.DD; 17/02032-8 - Development and experimental characterization of a block copolymer styrene-ethylene/butylene-styrene (SEBS) gel dosimeter for clinical dosimetry applications, BP.PD; 16/22374-8 - Blood oxygenation analysis in tumors using photoacoustic imaging, BP.DR; + associated scholarships 15/20299-6 - Photoacoustic imaging using transvaginal microconvex probe for ovarian cancer detection, BP.IC; 15/05684-0 - Laser and X-ray induced photoacoustic imaging, BP.DR; 14/26598-2 - Photoacoustic monitoring of tissue temperature during hyperthermia treatment, BP.MS; 14/21340-7 - Verification to dependence Power Doppler velocity for assessment of tissue vascularization, BP.IC - associated scholarships

Abstract

There are several reasons why conventional ultrasonography is one of the most widely used modalities in medical imaging. It provides high resolution images in real-time, it does not use ionizing radiation, it is portable, among others. However, this modality is not efficient when molecular and cellular events are to be imaged. Photoacoustic imaging, on the other hand, is a modality that uses ultrasonic waves and has shown promising results for the generation of molecular and cellular images. The photoacoustic imaging is based on the photoacoustic effect, where light absorption is converted into acoustic waves due to the thermoelastic expansion. For this reason, its contrast is related to the optical absorption spectra of tissues composed by different molecular structures. The photoacoustic signal is also depend on the viscoelastic properties of the medium. This research project involves the development of a system for tissue characterization using ultrasound and photoacoustic images simultaneously. To achieve that, nanoseconds laser pulses will be used to induce photoacoustic events in the tissue, generating, therefore, ultrasonic waves acquired by a conventional ultrasound imaging system. In addition to that, a photoacoustic Doppler system using megahertz modulated continuous wave laser systems will be developed for flow characterization. Those methods will be characterized and evaluated using specialized tissue-mimicking phantoms presenting appropriate optical and ultrasonic properties. (AU)

Scientific publications

(22)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HADADIAN, YASER; AZIMBAGIRAD, MEHRAN; NAVAS, ELCIO A.; PAVAN, THEO Z.. A versatile induction heating system for magnetic hyperthermia studies under different experimental conditions. Review of Scientific Instruments, v. 90, n. 7, 2019. (09/54082-2, 13/18854-6)

JOÃO HENRIQUE ULIANA; DIEGO RONALDO THOMAZ SAMPAIO; ANTONIO ADILTON OLIVEIRA CARNEIRO; THEO ZEFERINO PAVAN. Photoacoustic-based thermal image formation and optimization using an evolutionary genetic algorithm. Res. Biomed. Eng., v. 34, n. 2, p. 147-156, 2018-05-28. (13/18854-6, 14/26598-2, 15/05684-0)

CABRELLI, LUCIANA C.; GRILLO, FELIPE W.; SAMPAIO, DIEGO R. T.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. ACOUSTIC AND ELASTIC PROPERTIES OF GLYCEROL IN OIL-BASED GEL PHANTOMS. ULTRASOUND IN MEDICINE AND BIOLOGY, v. 43, n. 9, p. 2086-2094, SEP 2017. (13/18854-6)

CABRELLI, LUCIANA C.; ULIANA, JOAO H.; DA CRUZ JUNIOR, LUISMAR B.; BACHMANN, LUCIANO; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. Glycerol-in-SEBS gel as a material to manufacture stable wall-less vascular phantom for ultrasound and photoacoustic imaging. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, v. 7, n. 6, NOV 2021. (13/18854-6, 16/22374-8)

SANTOS, OLAVO; CANCINO-BERNARDI, JULIANA; PINCELA LINS, PAULA MARIA; SAMPAIO, DIEGO; PAVAN, THEO; ZUCOLOTTO, VALTENCIR. Near-Infrared Photoactive Theragnostic Gold Nanoflowers for Photoacoustic Imaging and Hyperthermia. ACS APPLIED BIO MATERIALS, v. 4, n. 9, p. 6780-6790, SEP 20 2021. (12/03570-0, 16/14303-3, 12/15630-7, 13/18854-6)

HADADIAN, YASER; RAMOS, ANA PAULA; PAVAN, THEO Z.. Role of zinc substitution in magnetic hyperthermia properties of magnetite nanoparticles: interplay between intrinsic properties and dipolar interactions. SCIENTIFIC REPORTS, v. 9, DEC 2 2019. (13/18854-6)

AMADO, ANDRE MIELE; ULIANA, JOAO HENRIQUE; PAVAN, THEO ZEFERINO; BORISSEVITCH, IOURI. Effect of metallization on porphyrin photoacoustic response. Chemical Physics Letters, v. 738, JAN 2020. (16/22374-8, 13/18854-6)

MAZON, E. E.; ARSALANI, SAEIDEH; ULIANA, JOAO H.; CARNEIRO, ANTONIO A. O.; GUALDI, ALEXANDRE J.; PAVAN, THEO Z.; IEEE. A pulsed magnetomotive ultrasound imaging system for magnetic nanoparticle detection. 2021 IEEE UFFC LATIN AMERICA ULTRASONICS SYMPOSIUM (LAUS), v. N/A, p. 4-pg., 2021-01-01. (13/18854-6)

MARTINS, MARICY R.; MARTINS, WELLINGTON P.; SOARES, CARLOS A. M.; MIYAGUE, ANDRE H.; KUDLA, MAREK J.; PAVAN, THEO Z.. Understanding the Influence of Flow Velocity, Wall Motion Filter, Pulse Repetition Frequency, and Aliasing on Power Doppler Image Quantification. JOURNAL OF ULTRASOUND IN MEDICINE, v. 37, n. 1, p. 255-261, JAN 2018. (14/21340-7, 13/18854-6)

CABRELLI, LUCIANA C.; PELISSARI, PEDRO I. B. G. B.; DEANA, ALESSANDRO M.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. Stable phantom materials for ultrasound and optical imaging. Physics in Medicine and Biology, v. 62, n. 2, p. 432-447, JAN 21 2017. (13/18854-6)

DIEGO RONALDO THOMAZ SAMPAIO; FELIPE WILKER GRILLO; ALEXANDRE COLELLO BRUNO; THEO ZEFERINO PAVAN; ANTONIO ADILTON OLIVEIRA CARNEIRO. A magneto-motive ultrasound platform designed for pre-clinical and clinical applications. Res. Biomed. Eng., v. 32, n. 4, p. 337-346, 2017-01-12. (13/18854-6, 10/07639-9, 12/18420-3)

GRILLO, F. W.; RONDINONI, C.; FILHO, A. C. S. S.; SIMOZO, F. H.; FARINA, J. A., JR.; PAVAN, T. Z.; MACHADO, H. R.; CARNEIRO, A. A. O.; COSTAFELIX, R; MACHADO, JC; et al. Virtual Surgical Planning: Patient-Specific Imaging Segmentation. XXVI BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2018, VOL 1, v. 70, n. 1, p. 4-pg., 2019-01-01. (13/18854-6)

HADADIAN, YASER; ULIANA, JOAO H.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. A Novel Theranostic Platform: Integration of Magnetomotive and Thermal Ultrasound Imaging With Magnetic Hyperthermia. IEEE Transactions on Biomedical Engineering, v. 68, n. 1, p. 68-77, JAN 2021. (16/22374-8, 13/18854-6)

ULIANA, JOAO H.; SAMPAIO, DIEGO R. T.; FERNANDES, GUILHERME S. P.; BRASSESCO, MARIA S.; NOGUEIRA-BARBOSA, MARCELLO H.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer. SENSORS, v. 20, n. 14, JUL 2020. (17/14482-8, 16/22374-8, 13/18854-6, 15/05684-0)

GRILLO, FELIPE W.; CABRELLI, LUCIANA C.; SAMPAIO, DIEGO R. T.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.; IEEE. Glycerol in oil-based phantom with improved performance for photoacoustic imaging. 2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), v. N/A, p. 4-pg., 2017-01-01. (15/05684-0, 13/18854-6)

. Photoacoustic-based thermal image formation and optimization using an evolutionary genetic algorithm. Res. Biomed. Eng., n. ahead, p. -, 2018. (15/05684-0, 13/18854-6, 14/26598-2)

HADADIAN, YASER; SAMPAIO, DIEGO R. T.; RAMOS, ANA P.; CARNEIRO, ANTONIO A. O.; MOZAFFARI, MORTEZA; CABRELLI, LUCIANA C.; PAVAN, THEO Z.. Synthesis and characterization of zinc substituted magnetite nanoparticles and their application to magneto-motive ultrasound imaging. Journal of Magnetism and Magnetic Materials, v. 465, p. 33-43, NOV 1 2018. (09/54082-2, 13/18854-6)

NOGUEIRA-BARBOSA, MARCELLO H.; LUGAO, HELENA B.; GREGIO-JUNIOR, EVERALDO; CREMA, MICHEL D.; KOBAYASHI, MARIANA T. T.; FRADE, MARCO A. C.; PAVAN, THEO Z.; CARNEIRO, ANTONIO A. O.. ULTRASOUND ELASTOGRAPHY ASSESSMENT OF THE MEDIAN NERVE IN LEPROSY PATIENTS. MUSCLE & NERVE, v. 56, n. 3, p. 393-398, SEP 2017. (13/18854-6)

SAMPAIO, D. R. T.; MARTINS, A. A. F.; CARNEIRO, A. A. O.; PAVONI, J. F.; PAVAN, T. Z.. X-Ray Acoustic Imaging: Towards Radiation Dose Assessment During Teletherapy. Medical Physics, v. 44, n. 6, p. 1-pg., 2017-06-01. (15/05684-0, 13/18854-6)

HADAIAN, YASER; SAMPAIO, DIEGO R. T.; RAMOS, ANA PAULA; CARNEIRO, ANTONIO. A. O.; PAVAN, THEO Z.; IEEE. Magneto-motive ultrasound imaging using superparamagnetic ferrite nanoparticle with enhanced saturation magnetization synthesized by a simple copreciptation method. 2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), v. N/A, p. 4-pg., 2017-01-01. (09/54082-2, 13/18854-6)

SAMPAIO, DIEGO R. T.; YALY, CAROLINA C.; PAVONI, JULIANA F.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. Radiotherapy Linear Accelerator-Based X-Ray Acoustic Imaging Using Linear Array Transducer and Its Relationship with Dose: Multidomain Simulation and In Vitro Experiments. Brazilian Journal of Physics, v. 51, n. 4, p. 1069-1078, AUG 2021. (15/05684-0, 13/18854-6)

ULIANA, JOAO H.; CANDIDO, MARINA F.; BRASSESCO, MARIA S.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.; IEEE. Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging to Evaluate Tumor Oxygenation. 2021 IEEE UFFC LATIN AMERICA ULTRASONICS SYMPOSIUM (LAUS), v. N/A, p. 4-pg., 2021-01-01. (16/22374-8, 13/18854-6)

Filed patent(s) as a result of this research project