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Photoacoustic and ultrasound imaging applied to tissue characterization

Grant number: 13/18854-6
Support type:Research Grants - Young Investigators Grants
Duration: July 01, 2014 - June 30, 2019
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal researcher:Theo Zeferino Pavan
Grantee:Theo Zeferino Pavan
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Antonio Adilton Oliveira Carneiro ; Iouri Borissevitch ; Marcello Henrique Nogueira Barbosa
Associated grant(s):21/06728-2 - Photoacoustic and ultrasound imaging for theranostic purposes, AP.JP2
19/13450-0 - 2019 IEEE International Ultrasonics Symposium, AR.EXT
14/26889-7 - Visits, conferences and scientific collaborations with the innovation group in medical instrumentation and ultrasound of USP in Ribeirão Preto, AV.EXT
Associated scholarship(s):17/14482-8 - Artifacts reduction on dual mode ultrasound/photoacoustic images, BP.DD
17/02032-8 - Development and experimental characterization of a block copolymer styrene-ethylene/butylene-styrene (SEBS) gel dosimeter for clinical dosimetry applications, BP.PD
16/22374-8 - Blood oxygenation analysis in tumors using photoacoustic imaging, BP.DR
+ associated scholarships 15/20299-6 - Photoacoustic imaging using transvaginal microconvex probe for ovarian cancer detection, BP.IC
15/05684-0 - Laser and X-ray induced photoacoustic imaging, BP.DR
14/26598-2 - Photoacoustic monitoring of tissue temperature during hyperthermia treatment, BP.MS
14/21340-7 - Verification to dependence Power Doppler velocity for assessment of tissue vascularization, BP.IC - associated scholarships

Abstract

There are several reasons why conventional ultrasonography is one of the most widely used modalities in medical imaging. It provides high resolution images in real-time, it does not use ionizing radiation, it is portable, among others. However, this modality is not efficient when molecular and cellular events are to be imaged. Photoacoustic imaging, on the other hand, is a modality that uses ultrasonic waves and has shown promising results for the generation of molecular and cellular images. The photoacoustic imaging is based on the photoacoustic effect, where light absorption is converted into acoustic waves due to the thermoelastic expansion. For this reason, its contrast is related to the optical absorption spectra of tissues composed by different molecular structures. The photoacoustic signal is also depend on the viscoelastic properties of the medium. This research project involves the development of a system for tissue characterization using ultrasound and photoacoustic images simultaneously. To achieve that, nanoseconds laser pulses will be used to induce photoacoustic events in the tissue, generating, therefore, ultrasonic waves acquired by a conventional ultrasound imaging system. In addition to that, a photoacoustic Doppler system using megahertz modulated continuous wave laser systems will be developed for flow characterization. Those methods will be characterized and evaluated using specialized tissue-mimicking phantoms presenting appropriate optical and ultrasonic properties. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CABRELLI, LUCIANA C.; ULIANA, JOAO H.; DA CRUZ JUNIOR, LUISMAR B.; BACHMANN, LUCIANO; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z. Glycerol-in-SEBS gel as a material to manufacture stable wall-less vascular phantom for ultrasound and photoacoustic imaging. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, v. 7, n. 6 NOV 2021. Web of Science Citations: 0.
SANTOS, OLAVO; CANCINO-BERNARDI, JULIANA; PINCELA LINS, PAULA MARIA; SAMPAIO, DIEGO; PAVAN, THEO; ZUCOLOTTO, VALTENCIR. Near-Infrared Photoactive Theragnostic Gold Nanoflowers for Photoacoustic Imaging and Hyperthermia. ACS APPLIED BIO MATERIALS, v. 4, n. 9, p. 6780-6790, SEP 20 2021. Web of Science Citations: 2.
SAMPAIO, DIEGO R. T.; YALY, CAROLINA C.; PAVONI, JULIANA F.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z. Radiotherapy Linear Accelerator-Based X-Ray Acoustic Imaging Using Linear Array Transducer and Its Relationship with Dose: Multidomain Simulation and In Vitro Experiments. Brazilian Journal of Physics, v. 51, n. 4, p. 1069-1078, AUG 2021. Web of Science Citations: 0.
HADADIAN, YASER; ULIANA, JOAO H.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z. A Novel Theranostic Platform: Integration of Magnetomotive and Thermal Ultrasound Imaging With Magnetic Hyperthermia. IEEE Transactions on Biomedical Engineering, v. 68, n. 1, p. 68-77, JAN 2021. Web of Science Citations: 3.
ULIANA, JOAO H.; SAMPAIO, DIEGO R. T.; FERNANDES, GUILHERME S. P.; BRASSESCO, MARIA S.; NOGUEIRA-BARBOSA, MARCELLO H.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z. Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer. SENSORS, v. 20, n. 14 JUL 2020. Web of Science Citations: 0.
AMADO, ANDRE MIELE; ULIANA, JOAO HENRIQUE; PAVAN, THEO ZEFERINO; BORISSEVITCH, IOURI. Effect of metallization on porphyrin photoacoustic response. Chemical Physics Letters, v. 738, JAN 2020. Web of Science Citations: 1.
HADADIAN, YASER; RAMOS, ANA PAULA; PAVAN, THEO Z. Role of zinc substitution in magnetic hyperthermia properties of magnetite nanoparticles: interplay between intrinsic properties and dipolar interactions. SCIENTIFIC REPORTS, v. 9, DEC 2 2019. Web of Science Citations: 0.
HADADIAN, YASER; AZIMBAGIRAD, MEHRAN; NAVAS, ELCIO A.; PAVAN, THEO Z. A versatile induction heating system for magnetic hyperthermia studies under different experimental conditions. Review of Scientific Instruments, v. 90, n. 7 2019. Web of Science Citations: 1.
HADADIAN, YASER; SAMPAIO, DIEGO R. T.; RAMOS, ANA P.; CARNEIRO, ANTONIO A. O.; MOZAFFARI, MORTEZA; CABRELLI, LUCIANA C.; PAVAN, THEO Z. Synthesis and characterization of zinc substituted magnetite nanoparticles and their application to magneto-motive ultrasound imaging. Journal of Magnetism and Magnetic Materials, v. 465, p. 33-43, NOV 1 2018. Web of Science Citations: 3.
MARTINS, MARICY R.; MARTINS, WELLINGTON P.; SOARES, CARLOS A. M.; MIYAGUE, ANDRE H.; KUDLA, MAREK J.; PAVAN, THEO Z. Understanding the Influence of Flow Velocity, Wall Motion Filter, Pulse Repetition Frequency, and Aliasing on Power Doppler Image Quantification. JOURNAL OF ULTRASOUND IN MEDICINE, v. 37, n. 1, p. 255-261, JAN 2018. Web of Science Citations: 3.
JOÃO HENRIQUE ULIANA; DIEGO RONALDO THOMAZ SAMPAIO; ANTONIO ADILTON OLIVEIRA CARNEIRO; THEO ZEFERINO PAVAN. Photoacoustic-based thermal image formation and optimization using an evolutionary genetic algorithm. Res. Biomed. Eng., v. 34, n. 2, p. 147-156, 2018-05-28.
CABRELLI, LUCIANA C.; GRILLO, FELIPE W.; SAMPAIO, DIEGO R. T.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z. ACOUSTIC AND ELASTIC PROPERTIES OF GLYCEROL IN OIL-BASED GEL PHANTOMS. ULTRASOUND IN MEDICINE AND BIOLOGY, v. 43, n. 9, p. 2086-2094, SEP 2017. Web of Science Citations: 5.
NOGUEIRA-BARBOSA, MARCELLO H.; LUGAO, HELENA B.; GREGIO-JUNIOR, EVERALDO; CREMA, MICHEL D.; KOBAYASHI, MARIANA T. T.; FRADE, MARCO A. C.; PAVAN, THEO Z.; CARNEIRO, ANTONIO A. O. ULTRASOUND ELASTOGRAPHY ASSESSMENT OF THE MEDIAN NERVE IN LEPROSY PATIENTS. MUSCLE & NERVE, v. 56, n. 3, p. 393-398, SEP 2017. Web of Science Citations: 2.
CABRELLI, LUCIANA C.; PELISSARI, PEDRO I. B. G. B.; DEANA, ALESSANDRO M.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z. Stable phantom materials for ultrasound and optical imaging. Physics in Medicine and Biology, v. 62, n. 2, p. 432-447, JAN 21 2017. Web of Science Citations: 14.
DIEGO RONALDO THOMAZ SAMPAIO; FELIPE WILKER GRILLO; ALEXANDRE COLELLO BRUNO; THEO ZEFERINO PAVAN; ANTONIO ADILTON OLIVEIRA CARNEIRO. A magneto-motive ultrasound platform designed for pre-clinical and clinical applications. Res. Biomed. Eng., v. 32, n. 4, p. 337-346, 2017-01-12.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

MATERIAL MIMETIZADOR DE TECIDOS BIOLÓGICOS (PHANTOM) E SEU USO BR1020150260180 - Universidade de São Paulo (USP) . Theo Zeferino Pavan; Antonio Adilton Oliveira Carneiro; Luciana Camargo Cabrelli - October 2015, 13