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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

An age- and sex-dependent role of catecholaminergic neurons in the control of breathing and hypoxic chemoreflex during postnatal development

Texto completo
Autor(es):
Patrone, Luis Gustavo A. [1] ; Capalbo, Aretuza C. [1] ; Marques, Danuzia A. [1] ; Bicego, Kenia C. [1] ; Gargaglioni, Luciane H. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, UNESP, FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Brain Research; v. 1726, JAN 1 2020.
Citações Web of Science: 0
Resumo

The respiratory system undergoes significant development during the postnatal phase. Maturation of brainstem catecholaminergic (CA) neurons is important for the control and modulation of respiratory rhythmogenesis, as well as for chemoreception in early life. We demonstrated an inhibitory role for CA neurons in CO2 chemosensitivity in neonatal and juvenile male and female rats, but information regarding their role in the hypoxic ventilatory response (HVR) is lacking. We evaluated the contribution of brainstem CA neurons in the HVR during postnatal (P) development (P7-8, P14-15 and P20-21) in male and female rats through chemical injury with conjugated saporin anti-dopamine beta-hydroxylase (D beta H-SAP, 420 ng.uL(-1)) injected in the fourth ventricle. Ventilation (V-E) and oxygen consumption were recorded one week after the lesion in unanesthetized rats during exposure to normoxia and hypoxia. Hypoxia reduced breathing variability in P7-8 control rats of both sexes. At P7-8, the HVR for lesioned males and females increased 27% and 24%, respectively. Additionally, the lesion reduced the normoxic breathing variability in both sexes at P7-8, but hypoxia partially reverted this effect. For P14-15, the increase in V-E during hypoxia was 30% higher for male and 24% higher for female lesioned animals. A sex-specific difference was detected at P20-21, as lesioned males exhibited a 24% decrease in the HVR, while lesioned females experienced a 22% increase. Furthermore, the hypoxia-induced body temperature reduction was attenuated in P20-21 lesioned females. We conclude that brainstem CA neurons modulate the HRV during the postnatal phase, and possibly thermoregulation during hypoxia. (AU)

Processo FAPESP: 15/04849-6 - Participação dos canais TRPV4 na termorregulação de endotermos
Beneficiário:Kênia Cardoso Bícego
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/24577-3 - Alterações neuroanatômicas e funcionais do sistema respiratório no sono e na vigília em um modelo experimental para doença de Alzheimer
Beneficiário:Luciane Helena Gargaglioni Batalhão
Modalidade de apoio: Auxílio à Pesquisa - Regular