| Texto completo | |
| Autor(es): |
de Quadros, V. P.
[1]
;
Tobar, N.
[2, 3]
;
Viana, L. R.
[1]
;
dos Santos, R. W.
[1]
;
Kiyataka, P. H. M.
[2, 4]
;
Gomes-Marcondes, M. C. C.
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, UNICAMP, Biol Inst, Dept Struct & Funct Biol, Lab Nutr & Canc, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Clin Hosp, Nucl Med Serv, Campinas, SP - Brazil
[4] Inst Food Technol ITAL Campinas, Packaging Technol Ctr Cetea, Campinas, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BONE & JOINT RESEARCH; v. 8, n. 12, p. 573-581, DEC 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Objectives Insufficient protein ingestion may affect muscle and bone mass, increasing the risk of osteoporotic fractures in the elderly, and especially in postmenopausal women. We evaluated how a low-protein diet affects bone parameters under gonadal hormone deficiency and the improvement led by hormone replacement therapy (HRT) with 17 beta-oestradiol. Methods Female Wistar rats were divided into control (C), ovariectomized (OVX), and 17 beta-oestradioltreated ovariectomized (OVX-HRT) groups, which were fed a control or an isocaloric low-protein diet (LP; 6.6% protein; seven animals per group). Morphometric, serum, and body composition parameters were assessed, as well as bone parameters, mechanical resistance, and mineralogy. Results The results showed that protein restriction negatively affected body chemical composition and bone metabolism by the sex hormone deficiency condition in the OVX group. The association between undernutrition and hormone deficiency led to bone and muscle mass loss and increased the fragility of the bone (as well as decreasing relative femoral weight, bone mineral density, femoral elasticity, peak stress, and stress at offset yield). Although protein restriction induced more severe adverse effects compared with the controls, the combination with HRT showed an improvement in minimizing these damaging effects, as it was seen that HRT had some efficacy in maintaining muscle and bone mass, preserving the bone resistance and minimizing some deleterious processes during the menopause. Conclusion Protein restriction has adverse effects on metabolism, leading to more severe menopausal symptoms, and HRT could minimize these effects. Therefore, special attention should be given to a balanced diet during menopause and HRT. (AU) | |
| Processo FAPESP: | 15/21890-0 - Efeito das dietas leucina, cetogênica e combinada no crescimento tumoral, estado caquético e perfil metabolômico sistêmico, muscular e tumoral de ratas portadoras de câncer caquexia (modelo carcinossarcoma de Walker 256) |
| Beneficiário: | Laís Rosa Viana |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/02739-4 - Nutrição e câncer: estudo dos aspectos moleculares, proteômicos e metabolômicos em modelo experimental de caquexia |
| Beneficiário: | Maria Cristina Cintra Gomes Marcondes |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/13334-7 - Nutrição e câncer: avaliação do perfil metabolômico, proteômico e das vias de sinalização celular muscular, placentária e fetal e do tecido tumoral sob influência dos hormônios da gravidez em ratas |
| Beneficiário: | Maria Cristina Cintra Gomes Marcondes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |