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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The 17 beta-oestradiol treatment minimizes the adverse effects of protein restriction on bone parameters in ovariectomized Wistar rats RELEVANCE TO OSTEOPOROSIS AND THE MENOPAUSE

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de Quadros, V. P. [1] ; Tobar, N. [2, 3] ; Viana, L. R. [1] ; dos Santos, R. W. [1] ; Kiyataka, P. H. M. [2, 4] ; Gomes-Marcondes, M. C. C. [1]
Total Authors: 6
[1] Univ Estadual Campinas, UNICAMP, Biol Inst, Dept Struct & Funct Biol, Lab Nutr & Canc, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Clin Hosp, Nucl Med Serv, Campinas, SP - Brazil
[4] Inst Food Technol ITAL Campinas, Packaging Technol Ctr Cetea, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: BONE & JOINT RESEARCH; v. 8, n. 12, p. 573-581, DEC 2019.
Web of Science Citations: 0

Objectives Insufficient protein ingestion may affect muscle and bone mass, increasing the risk of osteoporotic fractures in the elderly, and especially in postmenopausal women. We evaluated how a low-protein diet affects bone parameters under gonadal hormone deficiency and the improvement led by hormone replacement therapy (HRT) with 17 beta-oestradiol. Methods Female Wistar rats were divided into control (C), ovariectomized (OVX), and 17 beta-oestradioltreated ovariectomized (OVX-HRT) groups, which were fed a control or an isocaloric low-protein diet (LP; 6.6% protein; seven animals per group). Morphometric, serum, and body composition parameters were assessed, as well as bone parameters, mechanical resistance, and mineralogy. Results The results showed that protein restriction negatively affected body chemical composition and bone metabolism by the sex hormone deficiency condition in the OVX group. The association between undernutrition and hormone deficiency led to bone and muscle mass loss and increased the fragility of the bone (as well as decreasing relative femoral weight, bone mineral density, femoral elasticity, peak stress, and stress at offset yield). Although protein restriction induced more severe adverse effects compared with the controls, the combination with HRT showed an improvement in minimizing these damaging effects, as it was seen that HRT had some efficacy in maintaining muscle and bone mass, preserving the bone resistance and minimizing some deleterious processes during the menopause. Conclusion Protein restriction has adverse effects on metabolism, leading to more severe menopausal symptoms, and HRT could minimize these effects. Therefore, special attention should be given to a balanced diet during menopause and HRT. (AU)

FAPESP's process: 15/21890-0 - Effect of leucine, ketogenic and combined diets in tumor growth, cachectic state and metabolomic systemic profile, muscle and tumor in rats with cancer cachexia (Walker 256 model)
Grantee:Laís Rosa Viana
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/02739-4 - Nutrition and cancer: study of molecular, proteomic and metabolomic aspects of experimental model of cachexia
Grantee:Maria Cristina Cintra Gomes Marcondes
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/13334-7 - Nutrition and cancer: metabolomic, and proteomic profile of muscle, placental, fetal, and tumor cell signaling pathways in Walker-256 tumour-bearing pregnant rats submitted to leucine nutritional supplementation
Grantee:Maria Cristina Cintra Gomes Marcondes
Support type: Regular Research Grants