Goniothalamin-Related Styryl Lactones: Isolation, Synthesis, Biological Activity and Mode of Action

Autor(es)

Pilli, Ronaldo Aloise ^[1] ; de Toledo, Ian ^[1] ; Meirelles, Matheus Andrade ^[1] ; Grigolo, Thiago Augusto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Chem, Dept Organ Chem, POB 6154, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Current Medicinal Chemistry; v. 26, n. 41, p. 7372-7451, 2019.
• Citações Web of Science: 2

Resumo

This review covers the chemistry and biological aspects of goniothalamin-related styryl lactones isolated from natural sources. This family of secondary metabolites has been reported to display diverse uses in folk medicine, but only a limited number of these compounds have been throughly investigated regarding their biological profile. Herein, we cover the goniothalamin-related styryl lactones having a C6-C3-C4 framework which appeared in the literature for the first time in the period 2000-2017, and the reports on the synthesis, biological activity and mechanism of action which were published from 2007-2017. (AU)

• Processo FAPESP: 16/12541-4 - Abordagem biomimética para a síntese de alcalóides Stemona.
• Beneficiário: Ronaldo Aloise Pilli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs