Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats

Autor(es)

Samelo, Ricardo R. ^[1] ; de Medeiros, Paloma da Cunha ^[1] ; de Carvalho Cavalcante, Deborah N. ^[1] ; Aranha, Maria L. G. ^[1] ; Duarte, Fabio A. ^[2] ; de Castro, Italo B. ^[3] ; Ribeiro, Daniel A. ^[4] ; Perobelli, Juliana E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Mar, Lab Toxicol Expt LATOEX, Campus Baixada Santista, Sao Paulo, SP - Brazil

^[2] Univ Fed Santa Maria, Dept Quim, Santa Maria, RS - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Mar, Sao Paulo, SP - Brazil

^[4] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ENVIRONMENTAL TOXICOLOGY; v. 35, n. 5 DEC 2019.
• Citações Web of Science: 0

Resumo

Arsenic (As) can contaminate air, soil, water, and organisms through mobilization of natural mineralogical deposits or anthropogenic actions. Inorganic-As compounds are more toxic and widely available in aquatic environments, including drinking water reservoir catchments. Since little is known about its effects on prepubertal mammals, the present study focused on it. Hence, As was administered through drinking water to male Wistar rats from postnatal day 23 to 53. Negative control group received vehicle only (filtered water); As 1 group received AsNaO2 at 0.01 mg L-1 and As2 group received AsNaO2 at 10 mg L-1. It was investigated hepatic and renal toxicity of AsNaO2 (ie, histopathology and apoptosis analysis), as well as its mutagenicity (ie, micronucleus test in liver and bone marrow), cytotoxicity (ie, frequency and type of erythrocytes in blood), and genotoxicity (ie, comet assay in blood). Also, As determination was performed in hepatic and renal tissues. Data obtained revealed that immature organisms present a pattern of arsenic accumulation similar to that observed in adults, suggesting similarity in metabolic processes. In addition, liver showed to be an important target tissue for As toxicity in these experimental conditions, exhibiting infiltrate of defense cells, DNA damages, and increased apoptosis rates. (AU)

• Processo FAPESP: 15/25821-2 - Avaliação de parâmetros reprodutivos de ratos machos expostos ao arsenito de sódio: estudo de toxicidade juvenil
• Beneficiário: Paloma da Cunha de Medeiros
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica