Silk fibroin membranes with self-assembled globular structures for controlled drug release

Autor(es)

Tomoda, Bruno Thorihara ^[1] ; Corazza, Fulvio Gabriel ^[2] ; Beppu, Marisa Masumi ^[3] ; Lopes, Patricia Santos ^[2] ; de Moraes, Mariana Agostini ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Chem Engn, Rua Sao Nicolau 210, Diadema - Brazil

^[2] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Rua Sao Nicolau 210, Diadema - Brazil

^[3] Univ Estadual Campinas, Sch Chem Engn, Ave Albert Einstein 500, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Polymer Science; v. 137, n. 16 DEC 2019.
• Citações Web of Science: 0

Resumo

In this paper, we have evaluated the incorporation of a drug model and its release from silk fibroin (SF) membranes, analyzing the morphological, chemical, barrier, and biological properties. SF self-assembled into stable globular structures, encapsulating the drug, when diclofenac sodium (DS) was incorporated into SF solution prior to membranes preparation. The membranes showed biostatic action and prevented microorganism permeation. Kinetic studies indicate that DS was released in 120 min, with Fickian diffusion as the main mechanism of release. Results of this paper emphasize the potential of SF in wound healing, with good barrier and biological properties. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48763. (AU)

• Processo FAPESP: 16/17555-3 - Membranas de polímeros naturais contendo ativos para aplicação em curativos de alto desempenho
• Beneficiário: Mariana Agostini de Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular