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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Silk fibroin membranes with self-assembled globular structures for controlled drug release

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Author(s):
Tomoda, Bruno Thorihara [1] ; Corazza, Fulvio Gabriel [2] ; Beppu, Marisa Masumi [3] ; Lopes, Patricia Santos [2] ; de Moraes, Mariana Agostini [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Chem Engn, Rua Sao Nicolau 210, Diadema - Brazil
[2] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Rua Sao Nicolau 210, Diadema - Brazil
[3] Univ Estadual Campinas, Sch Chem Engn, Ave Albert Einstein 500, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Applied Polymer Science; v. 137, n. 16 DEC 2019.
Web of Science Citations: 0
Abstract

In this paper, we have evaluated the incorporation of a drug model and its release from silk fibroin (SF) membranes, analyzing the morphological, chemical, barrier, and biological properties. SF self-assembled into stable globular structures, encapsulating the drug, when diclofenac sodium (DS) was incorporated into SF solution prior to membranes preparation. The membranes showed biostatic action and prevented microorganism permeation. Kinetic studies indicate that DS was released in 120 min, with Fickian diffusion as the main mechanism of release. Results of this paper emphasize the potential of SF in wound healing, with good barrier and biological properties. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48763. (AU)

FAPESP's process: 16/17555-3 - Membranes of natural polymers with active compounds for application as high performance wound dressings
Grantee:Mariana Agostini de Moraes
Support type: Regular Research Grants