High-fat diet effects on the prostatic adenocarcinoma model and jaboticaba peel extract intake: protective response in metabolic disorders and liver histopathology

Autor(es)

Nogueira-Lima, Ellen ^[1] ; Lamas, Celina de Almeida ^[1] ; Baseggio, Andressa Mara ^{[1, 2]} ; Fernandes do Vale, Jessica Stephany ^[1] ; Marostica Junior, Mario Roberto ^[2] ; Alves Cagnon, Valeria Helena ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Dept Food & Nutr, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 72, n. 8 NOV 2019.
• Citações Web of Science: 2

Resumo

Prostate cancer (PCa), overweight and obesity are frequent worldwide health problems. Clinical studies have shown that increased high-fat diet (HFD) consumption is associated with higher incidence of PCa. Brazilian berries, such as Myrciaria jaboticaba (Vell.) Berg, present high polyphenol concentration in the peel and exhibit positive effects on metabolic disorders and hepatic lesions. Therefore, the aim of the study herein was to investigate the patented jaboticaba peel extract effects (PJE) on different metabolic parameters and liver histopathology in the transgenic adenocarcinoma of the mouse prostate model, receiving a either normolipid diet or HFD for 8 weeks. The results showed that PJE reduced insulin resistance and glucose intolerance, decreased hepatic lipid accumulation, and inflammatory markers such as PPAR gamma and TNF alpha, respectively. In conclusion, the PJE treatment promoted protective effects in the metabolism of insulin and glucose and liver imbalance caused by HFD intake in the PCa model, suggesting that it may be a good protector against metabolic disorders present in overweight and associated with PCa. (AU)

• Processo FAPESP: 18/04579-7 - Extrato de Jabuticaba: Resposta in vivo do adenocarcinoma de próstata em camundongos TRAMP associada à ingestão de dieta hiperlipídica e in vitro em células prostáticas tumorais humanas
• Beneficiário: Valéria Helena Alves Cagnon Quitete
• Modalidade de apoio: Auxílio à Pesquisa - Regular