Analysis of Quality of Life after Pleurodesis in Patients with Malignant Pleural Effusion

Autor(es)

Terra, Ricardo Mingarini ^[1] ; Costa, Priscila Berenice ^[1] ; Monteiro Dela Vega, Alberto Jorge ^[2] ; Xavier Nabuco Araujob, Pedro Henrique ^[2] ; Teixeira, Lisete Ribeiro ^[3] ; Pego-Fernandes, Paulo Manuel ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med FMUSP, Inst Canc Estado Sao Paulo, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Coracao, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RESPIRATION; v. 98, n. 6, p. 467-472, DEC 2019.
• Citações Web of Science: 0

Resumo

Background: Malignant pleural effusion is one of the most important complications of metastatic cancer, and recurrent pleural effusions do not only have an impact on survival but also cause a huge repercussion on a patient's quality of life. Objectives: The main objective was to describe quality of life status before and after pleurodesis in patients with malignant pleural effusion. Secondary, we aimed to find predictors of quality of life improvement in such a population. Methods: Retrospective analysis of a database collected prospectively. We included patients who underwent pleurodesis from June 2004 to July 2014. Quality of life was evaluated through the WHOQOL-BREF questionnaire and applied before and 30 days after pleurodesis. We used a paired t test and the Wilcoxon rank-sum to compare pre-/post-pleurodesis results, Kaplan-Meier curves for survival analysis, and multiple linear regressions to find predictors of quality of life improvement. Results: 183 patients were included (145 were women). Mean age was 58.3 +/- 12.3 years, the most numerous primary tumor was breast cancer. Median survival time was 9 months. Dyspnea was the most prevalent symptom. Baseline results showed that patients had low quality of life scores. After pleurodesis, there was a significant improvement in respiratory symptoms, physical domain, and general health. Linear regression showed an improvement in physical domain with the sclerosing agent nitrate (p = 0.005). Male gender (p = 0.002) and a higher lymphocyte count (p = 0.01) were inversely associated with improvement in physical domain. Conclusions: Pleurodesis improved symptoms and quality of life in patients with malignant pleural effusion. Gender, lymphocyte count, and sclerosing agent might interfere with quality of life improvement. (AU)

• Processo FAPESP: 09/50894-2 - Efetividade e seguranca da pleurodese ambulatorial com cateteres pleurais e nitrato de prata no derrame pleural maligno recidivante
• Beneficiário: So Yeon Kim
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica