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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Modular biogenesis of mitochondrial respiratory complexes

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Autor(es):
Barros, Mario H. [1] ; McStay, Gavin P. [2]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Microbiol, Inst Ciencias Biomed, Sao Paulo - Brazil
[2] Staffordshire Univ, Dept Biol Sci, Stoke On Trent, Staffs - England
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: MITOCHONDRION; v. 50, p. 94-114, JAN 2020.
Citações Web of Science: 0
Resumo

Mitochondrial function relies on the activity of oxidative phosphorylation to synthesise ATP and generate an electrochemical gradient across the inner mitochondrial membrane. These coupled processes are mediated by five multi-subunit complexes that reside in this inner membrane. These complexes are the product of both nuclear and mitochondrial gene products. Defects in the function or assembly of these complexes can lead to mitochondrial diseases due to deficits in energy production and mitochondrial functions. Appropriate biogenesis and function are mediated by a complex number of assembly factors that promote maturation of specific complex subunits to form the active oxidative phosphorylation complex. The understanding of the biogenesis of each complex has been informed by studies in both simple eukaryotes such as Saccharomyces cerevisiae and human patients with mitochondrial diseases. These studies reveal each complex assembles through a pathway using specific subunits and assembly factors to form kinetically distinct but related assembly modules. The current understanding of these complexes has embraced the revolutions in genomics and proteomics to further our knowledge on the impact of mitochondrial biology in genetics, medicine, and evolution. (AU)

Processo FAPESP: 19/05232-3 - Estudos de corregulação da biogênese do mitoribossomo e da montagem da citocromo c oxidase
Beneficiário:Mario Henrique de Barros
Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional