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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Systemic low-grade inflammation-associated lifestyle, diet, and genetic factors: A population-based cross-sectional study

Texto completo
Autor(es):
Norde, Marina M. [1] ; Fisberg, Regina M. [1] ; Marchioni, Dirce M. L. [1] ; Rogero, Marcelo Macedo [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: NUTRITION; v. 70, FEB 2020.
Citações Web of Science: 0
Resumo

Objectives: Systemic low-grade inflammation (SLGI) is an intermediary common condition to the physiopathology of chronic noncommunicable diseases and targeting its determinants could lead to more efficient public health strategies. We aimed to investigate SLGI-independent associations with lifestyle, diet, and genetic factors in a population-based sample of adults using a systemic low-grade inflammation score (SIS). Methods: The study sample is composed of 269 participants from the cross-sectional population-based Health Survey of Sao Paulo (2008-2010), ages 20 to 59 y, whose data on socioeconomic variables, lifestyle, health parameters, and blood samples were available. Diet was assessed by two 24-h recalls, and the Brazilian Health Eating Index-Revised (BHEI-R) was scored. From blood samples, 30 single nucleotide polymorphisms on inflammatory genes were genotyped, and plasma eleven inflammatory biomarkers levels that composed the SIS were determined. A multiple, stepwise, linear regression was used to investigate SIS-independent associated factors. Results: Factors independently associated with SIS were BHEI-R score (partial R-2 = 5.1; beta = -0.13: P = 0.003), body mass index (partial R-2 = 3.4; beta = 0.19; P = 0.001), TLR4 rs5030728 GA + AA genotype (partial R-2 = 3.1; beta = -1.37; P = 0.008), age 50 to 59 y (partial R-2 = 2.5; beta = 1.93; P = 0.029) in comparison with the reference category (20 to 29 y), and commuting physical activity >150 min/wk (partial R-2 = 2.2; beta = -1.29; P = 0.043) after adjustment for current smoking status, medication use, and dietary misreporting. Conclusions: Eating a lower quality diet, having a higher body mass index score and age, being GG homozygous for TLR4 rs5030728, and spending <150 min/wk in transportation physical activity are independent determinants of SLGI. (C) 2019 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 12/20401-7 - Associação entre SNP relacionados aos genes da adiponectina, proteína C reativa, TLR4, TNF-alfa, IL-1 beta, IL-6 e IL-10 e ingestão de lipídios e seus efeitos sobre a concentração plasmática de biomarcadores inflamatórios em estudo de base populacional
Beneficiário:Marcelo Macedo Rogero
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/15831-0 - Fatores dietéticos, homocisteína, polimorfismos do gene MTHFR e risco cardiovascular em adultos e idosos: estudo de base populacional - ISA - capital
Beneficiário:Regina Mara Fisberg
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/03803-5 - Associação de padrões alimentares e de polimorfismos de nucleotídeo único dos genes da adiponectina, receptor do tipo Toll 4, IL-1², IL-6, IL-10, TNF-±, CCL-2 e proteína C reativa com um padrão inflamatório sistêmico em um estudo de base populacional- ISA
Beneficiário:Marina Maintinguer Norde
Modalidade de apoio: Bolsas no Brasil - Doutorado