| Texto completo | |
| Autor(es): |
Norde, Marina M.
[1]
;
Fisberg, Regina M.
[1]
;
Marchioni, Dirce M. L.
[1]
;
Rogero, Marcelo Macedo
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRITION; v. 70, FEB 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Objectives: Systemic low-grade inflammation (SLGI) is an intermediary common condition to the physiopathology of chronic noncommunicable diseases and targeting its determinants could lead to more efficient public health strategies. We aimed to investigate SLGI-independent associations with lifestyle, diet, and genetic factors in a population-based sample of adults using a systemic low-grade inflammation score (SIS). Methods: The study sample is composed of 269 participants from the cross-sectional population-based Health Survey of Sao Paulo (2008-2010), ages 20 to 59 y, whose data on socioeconomic variables, lifestyle, health parameters, and blood samples were available. Diet was assessed by two 24-h recalls, and the Brazilian Health Eating Index-Revised (BHEI-R) was scored. From blood samples, 30 single nucleotide polymorphisms on inflammatory genes were genotyped, and plasma eleven inflammatory biomarkers levels that composed the SIS were determined. A multiple, stepwise, linear regression was used to investigate SIS-independent associated factors. Results: Factors independently associated with SIS were BHEI-R score (partial R-2 = 5.1; beta = -0.13: P = 0.003), body mass index (partial R-2 = 3.4; beta = 0.19; P = 0.001), TLR4 rs5030728 GA + AA genotype (partial R-2 = 3.1; beta = -1.37; P = 0.008), age 50 to 59 y (partial R-2 = 2.5; beta = 1.93; P = 0.029) in comparison with the reference category (20 to 29 y), and commuting physical activity >150 min/wk (partial R-2 = 2.2; beta = -1.29; P = 0.043) after adjustment for current smoking status, medication use, and dietary misreporting. Conclusions: Eating a lower quality diet, having a higher body mass index score and age, being GG homozygous for TLR4 rs5030728, and spending <150 min/wk in transportation physical activity are independent determinants of SLGI. (C) 2019 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 12/20401-7 - Associação entre SNP relacionados aos genes da adiponectina, proteína C reativa, TLR4, TNF-alfa, IL-1 beta, IL-6 e IL-10 e ingestão de lipídios e seus efeitos sobre a concentração plasmática de biomarcadores inflamatórios em estudo de base populacional |
| Beneficiário: | Marcelo Macedo Rogero |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 09/15831-0 - Fatores dietéticos, homocisteína, polimorfismos do gene MTHFR e risco cardiovascular em adultos e idosos: estudo de base populacional - ISA - capital |
| Beneficiário: | Regina Mara Fisberg |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/03803-5 - Associação de padrões alimentares e de polimorfismos de nucleotídeo único dos genes da adiponectina, receptor do tipo Toll 4, IL-1², IL-6, IL-10, TNF-±, CCL-2 e proteína C reativa com um padrão inflamatório sistêmico em um estudo de base populacional- ISA |
| Beneficiário: | Marina Maintinguer Norde |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |