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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Systemic low-grade inflammation-associated lifestyle, diet, and genetic factors: A population-based cross-sectional study

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Author(s):
Norde, Marina M. [1] ; Fisberg, Regina M. [1] ; Marchioni, Dirce M. L. [1] ; Rogero, Marcelo Macedo [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: NUTRITION; v. 70, FEB 2020.
Web of Science Citations: 0
Abstract

Objectives: Systemic low-grade inflammation (SLGI) is an intermediary common condition to the physiopathology of chronic noncommunicable diseases and targeting its determinants could lead to more efficient public health strategies. We aimed to investigate SLGI-independent associations with lifestyle, diet, and genetic factors in a population-based sample of adults using a systemic low-grade inflammation score (SIS). Methods: The study sample is composed of 269 participants from the cross-sectional population-based Health Survey of Sao Paulo (2008-2010), ages 20 to 59 y, whose data on socioeconomic variables, lifestyle, health parameters, and blood samples were available. Diet was assessed by two 24-h recalls, and the Brazilian Health Eating Index-Revised (BHEI-R) was scored. From blood samples, 30 single nucleotide polymorphisms on inflammatory genes were genotyped, and plasma eleven inflammatory biomarkers levels that composed the SIS were determined. A multiple, stepwise, linear regression was used to investigate SIS-independent associated factors. Results: Factors independently associated with SIS were BHEI-R score (partial R-2 = 5.1; beta = -0.13: P = 0.003), body mass index (partial R-2 = 3.4; beta = 0.19; P = 0.001), TLR4 rs5030728 GA + AA genotype (partial R-2 = 3.1; beta = -1.37; P = 0.008), age 50 to 59 y (partial R-2 = 2.5; beta = 1.93; P = 0.029) in comparison with the reference category (20 to 29 y), and commuting physical activity >150 min/wk (partial R-2 = 2.2; beta = -1.29; P = 0.043) after adjustment for current smoking status, medication use, and dietary misreporting. Conclusions: Eating a lower quality diet, having a higher body mass index score and age, being GG homozygous for TLR4 rs5030728, and spending <150 min/wk in transportation physical activity are independent determinants of SLGI. (C) 2019 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/20401-7 - Association between SNP related to adiponectin, C-reactive protein, Toll Like Receptor 4, TNF-alfa, IL-1 beta, IL-6 and IL-10 genes and lipids intake and their effects on plasma inflammatory biomarkers levels in population-based study
Grantee:Marcelo Macedo Rogero
Support Opportunities: Regular Research Grants
FAPESP's process: 09/15831-0 - Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital
Grantee:Regina Mara Fisberg
Support Opportunities: Regular Research Grants
FAPESP's process: 16/03803-5 - Association of dietary patterns and single nucleotide plymorphisms in the genes of adiponectin, Toll like receptor-4, IL-1², IL-6, IL-10, TNF-±, CCL-2 and C reactive protein with a systemic inflammatory pattern at a population-based study - ISA-Capital
Grantee:Marina Maintinguer Norde
Support Opportunities: Scholarships in Brazil - Doctorate